Publications

TREX2 Exonuclease Causes Spontaneous Mutations and Stress-Induced Replication Fork Defects in Cells Expressing RAD51K133A

December 22, 2020

Jun Ho Ko, Mi Young Son, Qing Zhou, Lucia Molnarova, Lambert Song, Jarmila Mlcouskova, Atis Jekabsons, Cristina Montagna, Lumir Krejci, Paul Hasty Cell Reports. 2020 Dec 22;33(12):108543. doi: 10.1016/j.celrep.2020.108543. Abstract: DNA damage tolerance (DDT) and homologous recombination (HR) stabilize replication forks (RFs). RAD18/UBC13/three prime repair exonuclease 2 (TREX2)-mediated proliferating cell nuclear antigen (PCNA) ubiquitination is […]

Development of a Geropathology Grading Platform for nonhuman primates

December 4, 2020

Katie J Olstad, Denise M Imai, Rebekah I Keesler, Rachel Reader, John H Morrison, Jeffery A Roberts, John P Capitanio, Elizabeth S Didier, Marcelo J Kuroda, Heather Simmons, Shabnam Salimi, Julie A Mattison, Yuji Ikeno, Warren Ladiges Aging Pathobiol Ther. 2020;2(1):16-19. doi: 10.31491/apt.2020.03.008. Abstract: A geropathology grading platform (GGP) for assessing age-related lesions has been […]

The CCR4-NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression

December 2, 2020

Taku Ito-Kureha, Takahisa Miyao, Saori Nishijima, Toru Suzuki, Shin-Ichi Koizumi, Alejandro Villar-Briones, Akinori Takahashi, Nobuko Akiyama, Masahiro Morita, Isao Naguro, Hiroki Ishikawa, Hidenori Ichijo, Taishin Akiyama, Tadashi Yamamoto Nat Commun. 2020 Dec 2;11(1):6169. doi: 10.1038/s41467-020-19975-4. Abstract: A repertoire of T cells with diverse antigen receptors is selected in the thymus. However, detailed mechanisms underlying this […]

Hepatocyte-specific PKCβ deficiency protects against high-fat diet-induced nonalcoholic hepatic steatosis

November 30, 2020

Yaoling Sh, Faizule Hassan, Vincenzo Coppola, Kedryn K Baskin, Xianlin Han, Neil K Mehta, Michael C Ostrowski, Kamal D Mehta Mol Metab. 2021 Feb:44:101133. doi: 10.1016/j.molmet.2020.101133. Epub 2020 Nov 30. Abstract: Objective: Nonalcoholic hepatic steatosis, also known as fatty liver, is a uniform response of the liver to hyperlipidic-hypercaloric diet intake. However, the post-ingestive signals […]

Canagliflozin extends life span in genetically heterogeneous male but not female mice

November 5, 2020

Richard A Miller, David E Harrison, David B Allison, Molly Bogue, Lucas Debarba, Vivian Diaz, Elizabeth Fernandez, Andrzej Galecki, W Timothy Garvey, Hashan Jayarathne, Navasuja Kumar, Martin A Javors, Warren C Ladiges, Francesca Macchiarini, James Nelson, Peter Reifsnyder, Nadia A Rosenthal, Marianna Sadagurski, Adam B Salmon, Daniel L Smith Jr, Jessica M Snyder, David B […]

Early disruption of nerve mitochondrial and myelin lipid homeostasis in obesity-induced diabetes

November 5, 2020

Juan P Palavicini, Juan Chen, Chunyan Wang, Jianing Wang, Chao Qin, Eric Baeuerle, Xinming Wang, Jung A Woo, David E Kang, Nicolas Musi, Jeffrey L Dupree, Xianlin Han. JCI Insight. 2020 Nov 5;5(21):137286. doi: 10.1172/jci.insight.137286. Abstract: Diabetic neuropathy is a major complication of diabetes. Current treatment options alleviate pain but do not stop the progression […]

Rapamycin-mediated mouse lifespan extension: Late-life dosage regimes with sex-specific effects

November 4, 2020

Randy Strong, Richard A Miller, Molly Bogue, Elizabeth Fernandez, Martin A Javors, Sergiy Libert, Paul Anthony Marinez, Michael P Murphy, Nicolas Musi, James F Nelson, Michael Petrascheck, Peter Reifsnyder, Arlan Richardson, Adam B Salmon, Francesca Macchiarini, David E Harrison Aging Cell. 2020 Nov;19(11):e13269. doi: 10.1111/acel.13269. Epub 2020 Nov 4. Abstract: To see if variations in […]

APOE2 is associated with longevity independent of Alzheimer’s disease

October 19, 2020

Mitsuru Shinohara, Takahisa Kanekiyo, Masaya Tachibana, Aishe Kurti, Motoko Shinohara, Yuan Fu, Jing Zhao, Xianlin Han, Patrick M Sullivan, G William Rebeck, John D Fryer, Michael G Heckman, Guojun Bu Elife. 2020 Oct 19:9:e62199. doi: 10.7554/eLife.62199. Abstract: Although the ε2 allele of apolipoprotein E (APOE2) benefits longevity, its mechanism is not understood. The protective effects […]

Primary neuron and astrocyte cultures from postnatal Callithrix jacchus: a non-human primate in vitro model for research in neuroscience, nervous system aging, and neurological diseases of aging

October 15, 2020

Angela O Dorigatti, Stacy A Hussong, Stephen F Hernandez, Aubrey M Sills, Adam B Salmon, Veronica Galvan Geroscience. 2021 Feb;43(1):115-124. doi: 10.1007/s11357-020-00284-z. Epub 2020 Oct 15. Abstract: The ability to generate in vitro cultures of neuronal cells has been instrumental in advancing our understanding of the nervous system. Rodent models have been the principal source […]

Diagnostic value of circulating cell-free mtDNA in patients with suspected thyroid cancer: ND4/ND1 ratio as a new potential plasma marker

October 7, 2020

Zhiying Jiang, Tyler Bahr, Chen Zhou, Tao Jin, Hao Chen, Shujie Song, Yuji Ikeno, Hengli Tian, Yidong Bai Mitochondrion. 2020 Nov:55:145-153. doi: 10.1016/j.mito.2020.09.007. Epub 2020 Oct 7. Abstract: Thyroid cancer is the most common endocrine malignancy, and its incidence continues to rise. For clinicians with cancer patients, choosing and interpreting diagnostic laboratory studies has become […]