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Selected Publications: (List of All Recent Publications)

15 Feb 2019 Marmoset as a model to study kidney changes associated with aging.

Marmoset as a model to study kidney changes associated with aging. Lee HJ, Gonzalez O, Dick EJ Jr, Donati A, Feliers D, Goutam Ghosh C, Ross C, Venkatachalam M, Tardif SD, Kasinath BS J Gerontol A Biol Sci Med Sci. 2019 Feb 15;74(3):315-324. doi: 10.1093/gerona/gly237. Abstract We evaluated whether the marmoset, a nonhuman primate, can […]

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1 Feb 2019 Age‐related changes in the marmoset gut microbiome

Age-related changes in the marmoset gut microbiome Reveles KR, Patel S, Forney L, Ross CN American Journal of Primatology. 2019 Feb;81(2):e22960. doi: 10.1002/ajp.22960. Epub 2019 Feb 25. Abstract The gut microbiome is known to play a significant role in human health but its role in aging remains unclear. The objective of this study was to […]

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23 Jan 2019 Rapamycin and Alzheimer’s disease: Time for a clinical trial?

Rapamycin and Alzheimer’s disease: Time for a clinical trial? Kaeberlein M, Galvan V Sci Transl Med. 2019 Jan 23;11(476). pii: eaar4289. doi: 10.1126/scitranslmed.aar4289. Abstract: The drug rapamycin has beneficial effects in a number of animal models of neurodegeneration and aging including mouse models of Alzheimer’s disease. Despite its compelling preclinical record, no clinical trials have […]

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12 Dec 2018 Effects of intravenous AICAR (5-aminoimidazole-4-carboximide riboside) administration on insulin signaling and resistance in premature baboons, Papio sp.

Effects of intravenous AICAR (5-aminoimidazole-4-carboximide riboside) administration on insulin signaling and resistance in premature baboons, Papio sp. Blanco CL, Gastaldelli A, Anzueto DG, Winter LA, Seidner SR, McCurnin DC, Liang H, Javors MA, DeFronzo RA, Musi N PLoS one. 2018 Dec 12;13(12):e0208757. doi: 10.1371/journal.pone.0208757. eCollection 2018. Abstract: Premature baboons exhibit peripheral insulin resistance and impaired […]

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1 Dec 2018 Thioredoxin overexpression in both the cytosol and mitochondria accelerates age-related disease and shortens lifespan in male C57BL/6 mice.

Thioredoxin overexpression in both the cytosol and mitochondria accelerates age-related disease and shortens lifespan in male C57BL/6 mice. Cunningham GM, Flores LC, Roman MG, Cheng C, Dube S, Allen C, Valentine JM, Hubbard GB, Bai Y, Saunders TL, Ikeno Y. GeroScience 2018 Dec;40(5-6):453-468. doi: 10.1007/s11357-018-0039-6. Epub 2018 Aug 18. Abstract To investigate the role of […]

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1 Dec 2018 Tau protein aggregation is associated with cellular senescence in the brain.

Tau protein aggregation is associated with cellular senescence in the brain. Musi N, Valentine JM, Sickora KR, Baeuerle E, Thompson CS, Shen Q, Orr ME. Aging Cell. 2018 Dec;17(6):e12840. doi: 10.1111/acel.12840. Epub 2018 Oct 11. Abstract Tau protein accumulation is the most common pathology among degenerative brain diseases, including Alzheimer’s disease (AD), progressive supranuclear palsy […]

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13 Nov 2018 NFκB Regulates Muscle Development and Mitochondrial Function.

NFκB Regulates Muscle Development and Mitochondrial Function. Valentine JM, Li ME, Shoelson SE, Zhang N, Reddick RL, Musi N J Gerontol A Biol Sci Med Sci. 2018 Nov 13. doi: 10.1093/gerona/gly262. [Epub ahead of print] Abstract: NFκB is a transcription factor that controls immune and inflammatory signaling pathways. In skeletal muscle, NFκB has been implicated […]

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9 Nov 2018 Tau‐induced nuclear envelope invagination causes a toxic accumulation of mRNA in Drosophila

Tau‐induced nuclear envelope invagination causes a toxic accumulation of mRNA in Drosophila Cornelison GL, Levy SA, Jenson T, Frost B Aging Cell. 2018 Nov 9:e12847. doi: 10.1111/acel.12847. [Epub ahead of print] Abstract The nucleus is a spherical dual-membrane bound organelle that encapsulates genomic DNA. In eukaryotes, messenger RNAs (mRNA) are transcribed in the nucleus and […]

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12 Oct 2018 Long-term treatment with the mTOR inhibitor rapamycin has minor effect on clinical laboratory markers in middle-aged marmosets.

Long-term treatment with the mTOR inhibitor rapamycin has minor effect on clinical laboratory markers in middle-aged marmosets. Sills AM, Artavia JM, DeRosa BD, Ross CN, Salmon AB American Journal of Primatology. 2018 Oct 12:e22927. doi: 10.1002/ajp.22927. [Epub ahead of print]. Abstract: Interventions to extend lifespan and improve health with increasing age would have significant impact […]

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1 Apr 2018 Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer’s disease and vascular cognitive impairment.

Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer’s disease and vascular cognitive impairment. Van Skike CE, Jahrling JB, Olson AB, Sayre NL, Hussong SA, Ungvari Z, Lechleiter JD, Galvan V. American Journal of Physiology – Heart and Circulatory Physiology. 2018 Apr 1. doi: 10.1152/ajpheart.00570.2017. Epub 2017 Dec 22. Abstract An intact blood-brain […]

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