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12 Nov 2018 Congratulations to Dr. Bess Frost for her publication in Aging Cell

Tau‐induced nuclear envelope invagination causes a toxic accumulation of mRNA in Drosophila Cornelison GL, Levy SA, Jenson T, Frost B Aging Cell. 2018 Nov 9:e12847. doi: 10.1111/acel.12847. [Epub ahead of print] Abstract The nucleus is a spherical dual-membrane bound organelle that encapsulates genomic DNA. In eukaryotes, messenger RNAs (mRNA) are transcribed in the nucleus and […]

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26 Oct 2018 Congratulations to Dr. Balakuntalam Kasinath for his publication in The Journals of Gerontology

Marmoset as a model to study kidney changes associated with aging. Lee HJ, Gonzalez O, Dick EJ Jr, Donati A, Feliers D, Goutam Ghosh C, Ross C, Venkatachalam M, Tardif SD, Kasinath BS J Gerontol A Biol Sci Med Sci. 2018 Oct 13. doi: 10.1093/gerona/gly237. [Epub ahead of print] DOI: 10.1093/gerona/gly237 Abstract We evaluated whether […]

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26 Oct 2018 Congratulations to Dr. Balakuntalam Kasinath for his publication in Geroscience

Hydrogen sulfide ameliorates aging-associated changes in the kidney. Lee HJ, Feliers D, Barnes JL, Oh S, Choudhury GG2, Diaz V, Galvan V, Strong R, Nelson J, Salmon A, Kevil CG, Kasinath BS Geroscience. 2018 Apr;40(2):163-176. doi: 10.1007/s11357-018-0018-y. Epub 2018 May 1. PMCID: PMC5964063 Abstract Aging is associated with replacement of normal kidney parenchyma by fibrosis. […]

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24 Aug 2018 “Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer’s disease and vascular cognitive impairment.”

Van Skike CE, Jahrling JB, Olson AB, Sayre NL, Hussong SA, Ungvari Z, Lechleiter JD, Galvan V. Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer’s disease and vascular cognitive impairment. American Journal of Physiology – Heart and Circulatory Physiology. 2018 Apr 1. doi: 10.1152/ajpheart.00570.2017. Epub 2017 Dec 22.

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24 Aug 2018 “Thioredoxin overexpression in both the cytosol and mitochondria accelerates age-related disease and shortens lifespan in male C57BL/6 mice.”

Cunningham GM, Flores LC, Roman MG, Cheng C, Dube S, Allen C, Valentine JM, Hubbard GB, Bai Y, Saunders TL, Ikeno Y. Thioredoxin overexpression in both the cytosol and mitochondria accelerates age-related disease and shortens lifespan in male C57BL/6 mice. GeroScience (2018). https://doi.org/10.1007/s11357-018-0039-6

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20 Aug 2018 “Tau protein aggregation is associated with cellular senescence in the brain”

Musi, N. , Valentine, J. M., Sickora, K. R., Baeuerle, E. , Thompson, C. S., Shen, Q. and Orr, M. E. (2018), Tau protein aggregation is associated with cellular senescence in the brain. Aging Cell. Accepted Author Manuscript. . doi:10.1111/acel.12840.

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19 Feb 2016 “Determinants of rodent longevity in the chaperone-protein degradation network.”

Rodriguez KA, Valentine JM, Kramer DA, Gelfond JA, Kristan DM, Nevo E, Buffenstein R. Determinants of rodent longevity in the chaperone-protein degradation network. Cell Stress Chaperones. 2016 Feb 19. [Epub ahead of print] PubMed PMID: 26894765.

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1 Feb 2016 “Graded Proteasome Dysfunction in Caenorhabditis elegans Activates an Adaptive Response Involving the Conserved SKN-1 and ELT-2 Transcription Factors and the Autophagy-Lysosome Pathway.”

Keith SA, Maddux SK, Zhong Y, Chinchankar MN, Ferguson AA, Ghazi A, Fisher AL. Graded Proteasome Dysfunction in Caenorhabditis elegans Activates an Adaptive Response Involving the Conserved SKN-1 and ELT-2 Transcription Factors and the Autophagy-Lysosome Pathway. PLoS Genet. 2016 Feb 1;12(2):e1005823. doi: 10.1371/journal.pgen.1005823. eCollection 2016 Feb. PubMed PMID: 26828939; PubMed Central PMCID: PMC4734690.

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7 Nov 2015 “Metabolic consequences of long-term rapamycin exposure on common marmoset monkeys (Callithrix jacchus).”

Ross C, Salmon A, Strong R, Fernandez E, Javors M, Richardson A, Tardif S. Metabolic consequences of long-term rapamycin exposure on common marmoset monkeys (Callithrix jacchus). Aging (Albany NY). 2015 Nov;7(11):964-73. PubMed PMID: 26568298; PubMed Central PMCID: PMC4694066.

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28 Sep 2015 “Dynamic differences in oxidative stress and the regulation of metabolism with age in visceral versus subcutaneous adipose”

Liu R, Pulliam DA, Liu Y, Salmon AB. Dynamic differences in oxidative stress and the regulation of metabolism with age in visceral versus subcutaneous adipose. Redox Biol. 2015 Sep 3;6:401-408. doi: 10.1016/j.redox.2015.07.014. [Epub ahead of print] PubMed PMID: 26355396.

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