Publications

Comparative lifespan and healthspan of nonhuman primate species common to biomedical research

August 6, 2024

Hillary F Huber, Hannah C Ainsworth, Ellen Quillen, Adam Salmon, Corinna Ross, Adinda D Azhar, Karen Bales, Michele A Basso, Kris Coleman, Ricki Colman, Huda S Darusman, William Hopkins, Charlotte E Hotchkiss, Matt Jorgensen, Kylie Kavanagh, Cun Li, Julie A Mattison, Peter W Nathanielsz, Suryo Saputro, Diana Scorpio, Paul-Michael Sosa, Eric Vallender, Yaomin Wang, Caroline […]

Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function

August 6, 2024

Binsheng Wang, Lichao Wang, Nathan S Gasek, Chia-Ling Kuo, Jia Nie, Taewan Kim, Pengyi Yan, Junyu Zhu, Blake L Torrance, Yueying Zhou, Lisa C Flores, Colton Allen, Allison M Andrade, Chun Guo, Rachel L Cohn, Evan R Jellison, Jenna M Bartley, George A Kuchel, Sheng Li, Tamar Pirtskhalava, Tamar Tchkonia, Sumit Yadav, Laura Haynes, James […]

A pilot study evaluating dosing tolerability of 17α-estradiol in male common marmosets (Callithrix jacchus)

August 6, 2024

Roshini Sathiaseelan, Jose V V Isola, Roberto Santín-Márquez, Daniel Adekunbi, Michal Fornalik, Adam B Salmon, Michael B Stout Geroscience. 2024 Aug 6. doi: 10.1007/s11357-024-01311-z. Online ahead of print. Abstract: 17α-estradiol extends healthspan and lifespan in male mice without significant feminization or deleterious effects on reproductive function, making it a candidate for human translation. However, studies […]

Wnt/Wingless signaling promotes lipid mobilization through signal-induced transcriptional repression

July 5, 2024

Mengmeng Liu, Rajitha-Udakara-Sampath Hemba-Waduge, Xiao Li, Xiahe Huang, Tzu-Hao Liu, Xianlin Han, Yingchun Wang, Jun-Yuan Ji Proc Natl Acad Sci U S A. 2024 Jul 9;121(28):e2322066121. doi: 10.1073/pnas.2322066121. Epub 2024 Jul 5. Abstract: The Wnt/Wingless signaling pathway plays critical roles in metazoan development and energy metabolism, but its role in regulating lipid homeostasis remains not […]

Development of primary osteoarthritis during aging in genetically diverse UM-HET3 mice

June 8, 2024

Sher Bahadur Poudel, Ryan R Ruff, Gozde Yildirim, Richard A Miller, David E Harrison, Randy Strong, Thorsten Kirsch, Shoshana Yakar Arthritis Res Ther. 2024 Jun 8;26(1):118. doi: 10.1186/s13075-024-03349-y. Abstract: Background: Primary osteoarthritis (OA) occurs without identifiable underlying causes such as previous injuries or specific medical conditions. Age is a major contributing factor to OA, and […]

Hypothalamic sex-specific metabolic shift by canagliflozin during aging

May 27, 2024

Hashan S M Jayarathne, Ryan Sullivan, Lukas Stilgenbauer, Lucas K Debarba, Artur Kuchumov, Lisa Koshko, Sydney Scofield, Wanqing Liu, Brett C Ginsburg, Richard A Miller, Marianna Sadagurski Geroscience. 2024 Oct;46(5):4479-4493. doi: 10.1007/s11357-024-01214-z. Epub 2024 May 27. Abstract: The hypothalamus undergoes significant changes with aging and plays crucial roles in age-related metabolic alterations. Sodium-glucose co-transporter 2 […]

Impact of long-term rapamycin treatment on age-related osteoarthritis in common marmoset

May 17, 2024

Dennis M Minton, Aditya R Ailiani, Michael D K Focht, Mariana E Kersh, Angela J Marolf, Kelly S Santangelo, Adam B Salmon, Adam R Konopka bioRxiv [Preprint]. 2024 May 17:2024.05.14.594256. doi: 10.1101/2024.05.14.594256. Abstract: Objective: Pharmacologic inhibition of the mechanistic target of rapamycin (mTOR) can attenuate experimental osteoarthritis (OA) in young, male preclinical models. However, the […]

Ketogenic diet induces p53-dependent cellular senescence in multiple organs

May 17, 2024

Sung-Jen Wei, Joseph R Schell, E Sandra Chocron, Mahboubeh Varmazyad, Guogang Xu, Wan Hsi Chen, Gloria M Martinez, Felix F Dong, Prethish Sreenivas, Rolando Trevino Jr, Haiyan Jiang, Yan Du, Afaf Saliba, Wei Qian, Brandon Lorenzana, Alia Nazarullah, Jenny Chang, Kumar Sharma, Erin Munkácsy, Nobuo Horikoshi, David Gius Sci Adv. 2024 May 17;10(20):eado1463. doi: 10.1126/sciadv.ado1463. […]

Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered metabolism, cell senescence, and nonalcoholic fatty liver disease

May 17, 2024

Guogang Xu, Songhua Quan, Joseph Schell, Yucheng Gao, Mahboubeh Varmazyad, Prethish Sreenivas, Diego Cruz, Haiyan Jiang, Meixia Pan, Xianlin Han, Juan Pablo Palavicini, Peng Zhao, Xiaoli Sun, Erik D Marchant, Blake B Rasmussen, Guannan Li, Sakie Katsumura, Masahiro Morita, Erin Munkácsy, Nobuo Horikoshi, E Sandra Chocron, David Gius Sci Adv. 2024 May 17;10(20):eadj5942. doi: 10.1126/sciadv.adj5942. […]

Lifespan effects in male UM-HET3 mice treated with sodium thiosulfate, 16-hydroxyestriol, and late-start canagliflozin

May 16, 2024

Richard A Miller, David E Harrison, Gino A Cortopassi, Ishmael Dehghan, Elizabeth Fernandez, Michael Garratt, John G Geisler, Brett C Ginsburg, Melissa L Han, Catherine C Kaczorowski, Navasuja Kumar, Scott F Leiser, Marisa Lopez-Cruzan, Ginger Milne, James R Mitchell, James F Nelson, Peter C Reifsnyder, Adam B Salmon, Ron Korstanje, Nadia Rosenthal, Randy Strong Geroscience. […]