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19 Dec 2018 Congratulations to Dr. Adam Salmon for his publication in the American Journal of Primatology

Long-term treatment with the mTOR inhibitor rapamycin has minor effect on clinical laboratory markers in middle-aged marmosets. Sills AM, Artavia JM, DeRosa BD, Ross CN, Salmon AB American Journal of Primatology. 2018 Oct 12:e22927. doi: 10.1002/ajp.22927. [Epub ahead of print]. Abstract: Interventions to extend lifespan and improve health with increasing age would have significant impact […]

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14 Dec 2018 Congratulations to Dr. Nicolas Musi for his publication in PLOS ONE

Effects of intravenous AICAR (5-aminoimidazole-4-carboximide riboside) administration on insulin signaling and resistance in premature baboons, Papio sp. Blanco CL, Gastaldelli A, Anzueto DG, Winter LA, Seidner SR, McCurnin DC, Liang H, Javors MA, DeFronzo RA, Musi N PLoS one. 2018 Dec 12;13(12):e0208757. doi: 10.1371/journal.pone.0208757. eCollection 2018. Abstract: Premature baboons exhibit peripheral insulin resistance and impaired […]

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14 Dec 2018 Congratulations to Dr. Nicolas Musi for his publication in The Journals of Gerontology

NFκB Regulates Muscle Development and Mitochondrial Function. Valentine JM, Li ME, Shoelson SE, Zhang N, Reddick RL, Musi N J Gerontol A Biol Sci Med Sci. 2018 Nov 13. doi: 10.1093/gerona/gly262. [Epub ahead of print] Abstract: NFκB is a transcription factor that controls immune and inflammatory signaling pathways. In skeletal muscle, NFκB has been implicated […]

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12 Nov 2018 Congratulations to Dr. Bess Frost for her publication in Aging Cell

Tau‐induced nuclear envelope invagination causes a toxic accumulation of mRNA in Drosophila Cornelison GL, Levy SA, Jenson T, Frost B Aging Cell. 2018 Nov 9:e12847. doi: 10.1111/acel.12847. [Epub ahead of print] Abstract The nucleus is a spherical dual-membrane bound organelle that encapsulates genomic DNA. In eukaryotes, messenger RNAs (mRNA) are transcribed in the nucleus and […]

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26 Oct 2018 Congratulations to Dr. Balakuntalam Kasinath for his publication in The Journals of Gerontology

Marmoset as a model to study kidney changes associated with aging. Lee HJ, Gonzalez O, Dick EJ Jr, Donati A, Feliers D, Goutam Ghosh C, Ross C, Venkatachalam M, Tardif SD, Kasinath BS J Gerontol A Biol Sci Med Sci. 2018 Oct 13. doi: 10.1093/gerona/gly237. [Epub ahead of print] DOI: 10.1093/gerona/gly237 Abstract We evaluated whether […]

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26 Oct 2018 Congratulations to Dr. Balakuntalam Kasinath for his publication in Geroscience

Hydrogen sulfide ameliorates aging-associated changes in the kidney. Lee HJ, Feliers D, Barnes JL, Oh S, Choudhury GG2, Diaz V, Galvan V, Strong R, Nelson J, Salmon A, Kevil CG, Kasinath BS Geroscience. 2018 Apr;40(2):163-176. doi: 10.1007/s11357-018-0018-y. Epub 2018 May 1. PMCID: PMC5964063 Abstract Aging is associated with replacement of normal kidney parenchyma by fibrosis. […]

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24 Aug 2018 “Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer’s disease and vascular cognitive impairment.”

Van Skike CE, Jahrling JB, Olson AB, Sayre NL, Hussong SA, Ungvari Z, Lechleiter JD, Galvan V. Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer’s disease and vascular cognitive impairment. American Journal of Physiology – Heart and Circulatory Physiology. 2018 Apr 1. doi: 10.1152/ajpheart.00570.2017. Epub 2017 Dec 22.

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24 Aug 2018 “Thioredoxin overexpression in both the cytosol and mitochondria accelerates age-related disease and shortens lifespan in male C57BL/6 mice.”

Cunningham GM, Flores LC, Roman MG, Cheng C, Dube S, Allen C, Valentine JM, Hubbard GB, Bai Y, Saunders TL, Ikeno Y. Thioredoxin overexpression in both the cytosol and mitochondria accelerates age-related disease and shortens lifespan in male C57BL/6 mice. GeroScience (2018). https://doi.org/10.1007/s11357-018-0039-6

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20 Aug 2018 “Tau protein aggregation is associated with cellular senescence in the brain”

Musi, N. , Valentine, J. M., Sickora, K. R., Baeuerle, E. , Thompson, C. S., Shen, Q. and Orr, M. E. (2018), Tau protein aggregation is associated with cellular senescence in the brain. Aging Cell. Accepted Author Manuscript. . doi:10.1111/acel.12840.

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19 Feb 2016 “Determinants of rodent longevity in the chaperone-protein degradation network.”

Rodriguez KA, Valentine JM, Kramer DA, Gelfond JA, Kristan DM, Nevo E, Buffenstein R. Determinants of rodent longevity in the chaperone-protein degradation network. Cell Stress Chaperones. 2016 Feb 19. [Epub ahead of print] PubMed PMID: 26894765.

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