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Selected Publications: (List of All Recent Publications)

7 Nov 2015 Metabolic consequences of long-term rapamycin exposure on common marmoset monkeys (Callithrix jacchus).

Metabolic consequences of long-term rapamycin exposure on common marmoset monkeys (Callithrix jacchus). Ross C, Salmon A, Strong R, Fernandez E, Javors M, Richardson A, Tardif S. Aging (Albany NY). 2015 Nov;7(11):964-73. doi: 10.18632/aging.100843. Abstract Rapamycin has been shown to extend lifespan in rodent models, but the effects on metabolic health and function have been widely […]

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30 Jun 2015 p53 and rapamycin are additive.

p53 and rapamycin are additive. Christy B, Demaria M, Campisi J, Huang J, Jones D, Dodds SG, Williams C, Hubbard G, Livi CB, Gao X, Weintraub S, Curiel T, Sharp ZD, Hasty P. Oncotarget. 2015 Jun 30;6(18):15802-13. doi: 10.18632/oncotarget.4602. Abstract Mechanistic target of rapamycin (mTOR) is a kinase found in a complex (mTORC1) that enables […]

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15 Jun 2015 Obesity-induced oxidative stress, accelerated functional decline with age and increased mortality in mice

Obesity-induced oxidative stress, accelerated functional decline with age and increased mortality in mice. Zhang Y, Fischer KE, Soto V, Liu Y, Sosnowska D, Richardson A, Salmon AB. Arch Biochem Biophys. 2015 Jun 15;576:39-48. doi: 10.1016/j.abb.2014.12.018. Epub 2015 Jan 3. Abstract Obesity is a serious chronic disease that increases the risk of numerous co-morbidities including metabolic […]

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15 Jun 2015 The paradoxical role of thioredoxin on oxidative stress and aging.

The paradoxical role of thioredoxin on oxidative stress and aging. Cunningham GM, Roman MG, Flores LC, Hubbard GB, Salmon AB, Zhang Y, Gelfond J, Ikeno Y. Arch Biochem Biophys. 2015 Jun 15;576:32-8. doi: 10.1016/j.abb.2015.02.025. Epub 2015 Feb 26. Abstract In spite of intensive study, there is still controversy about the free radical or oxidative stress […]

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29 Jan 2015 Reduced expression of MYC increases longevity and enhances healthspan.

Reduced expression of MYC increases longevity and enhances healthspan. Hofmann JW1, Zhao X, De Cecco M, Peterson AL, Pagliaroli L, Manivannan J, Hubbard GB, Ikeno Y, Zhang Y, Feng B, Li X, Serre T, Qi W, Van Remmen H, Miller RA, Bath KG, de Cabo R, Xu H, Neretti N, Sedivy JM. Cell. 2015 Jan […]

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14 May 2014 Identification of Ssm1b, a novel modifier of DNA methylation, and its expression during mouse embryogenesis

Identification of Ssm1b, a novel modifier of DNA methylation, and its expression during mouse embryogenesis. Ratnam S, Engler P, Bozek G, Mao L, Podlutsky A, Austad S, Martin T, Storb U.  Development. 2014 May;141(10):2024-34. doi: 10.1242/dev.105726. Abstract The strain-specific modifier Ssm1 is responsible for the strain-dependent methylation of particular E. coli gpt-containing transgenic sequences. Here, […]

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