Nathan Shock Center
June 12, 2021
Tatiana D Saccon, Augusto Schneider, Cindi G Marinho, Allancer D C Nunes, Sarah Noureddine, Joseph Dhahbi, Yury O Nunez Lopez, Gage LeMunyan, Roberto Salvatori, Carla R P Oliveira, Alécia A Oliveira-Santos, Nicolas Musi, Andrzej Bartke, Manuel H Aguiar-Oliveira, Michal M Masternak Aging Cell. 2021 Jul;20(7):e13420. doi: 10.1111/acel.13420. Epub 2021 Jun 12. Abstract: Reduced inflammation, increased […]
June 12, 2021
Hak Joo Lee, Andrew Donati, Denis Feliers, Yuyang Sun, Yanli Ding, Muniswamy Madesh, Adam B Salmon, Yuji Ikeno, Corinna Ross, Christopher L O’Connor, Wenjun Ju, Markus Bitzer, Yidong Chen, Goutam Ghosh Choudhury, Brij B Singh, Kumar Sharma, Balakuntalam S Kasinath Aging Cell. 2021 Jul;20(7):e13407. doi: 10.1111/acel.13407. Epub 2021 Jun 12. Abstract: The mechanism of kidney […]
June 7, 2021
Nicholas F Fitz, Kyong Nyon Nam, Cody M Wolfe, Florent Letronne, Brittany E Playso, Bistra E Iordanova, Takashi D Y Kozai, Richard J Biedrzycki, Valerian E Kagan, Yulia Y Tyurina, Xianlin Han, Iliya Lefterov, Radosveta Koldamova Nat Commun. 2021 Jun 7;12(1):3416. doi: 10.1038/s41467-021-23762-0. Abstract: APOE and Trem2 are major genetic risk factors for Alzheimer’s disease […]
June 5, 2021
Daniel A Adekunbi, Cun Li, Peter W Nathanielsz, Adam B Salmon Geroscience. 2021 Aug;43(4):2067-2085. doi: 10.1007/s11357-021-00395-1. Epub 2021 Jun 5. Abstract: Aging is associated with progressive loss of cellular homeostasis resulting from intrinsic and extrinsic challenges. Lack of a carefully designed, well-characterized, precise, translational experimental model is a major limitation to understanding the cellular perturbations […]
June 3, 2021
Jonathan D Dorigatti, Kevin M Thyne, Brett C Ginsburg, Adam B Salmon Biochem Biophys Rep. 2021 Jun 3:27:101040. doi: 10.1016/j.bbrep.2021.101040. eCollection 2021 Sep. Abstract: Activation of AMP activated protein kinase (AMPK) signaling has been demonstrated to extend lifespan and improve healthspan across multiple species. This suggests pharmaceutical approaches to increase AMPK hold the potential to […]
May 24, 2021
Yun Shi, Jason Pizzini, Hanzhou Wang, Falguni Das, Parveez Ahamed Abdul Azees, Goutam Ghosh Choudhury, Jeffrey L Barnes, Mengwei Zang, Susan T Weintraub, Chih-Ko Yeh, Michael S Katz, Amrita Kamat Am J Physiol Endocrinol Metab. 2021 Jul 1;321(1):E90-E104. doi: 10.1152/ajpendo.00651.2020. Epub 2021 May 24. Abstract: Nonalcoholic fatty liver disease (NAFLD) is a spectrum of disorders […]
April 23, 2021
Jonathan D Dorigatti, Kevin M Thyne, Brett C Ginsburg, Adam B Salmon Geroscience. 2021 Jun;43(3):1497-1511. doi: 10.1007/s11357-021-00372-8. Epub 2021 Apr 23. Abstract: AMP-activated protein kinase (AMPK) is a central regulator of both lifespan and health across multiple model organisms. β-Guanidinopropionic acid (GPA) is an endogenous AMPK activator previously shown to improve metabolic function in young […]
April 22, 2021
Candice E Van Skike, Stacy A Hussong, Stephen F Hernandez, Andy Q Banh, Nicholas DeRosa, Veronica Galvan J Neurosci. 2021 May 12;41(19):4305-4320. doi: 10.1523/JNEUROSCI.2144-20.2021. Epub 2021 Apr 22. Abstract: Vascular dysfunction is a universal feature of aging and decreased cerebral blood flow has been identified as an early event in the pathogenesis of Alzheimer’s disease […]
March 31, 2021
David E Harrison, Randy Strong, Peter Reifsnyder, Navasuja Kumar, Elizabeth Fernandez, Kevin Flurkey, Martin A Javors, Marisa Lopez-Cruzan, Francesca Macchiarini, James F Nelson, Adrian Markewych, Alessandro Bitto, Amy L Sindler, Gino Cortopassi, Kylie Kavanagh, Lin Leng, Richard Bucala, Nadia Rosenthal, Adam Salmon, Timothy M Stearns, Molly Bogue, Richard A Miller Aging Cell. 2021 May;20(5):e13328. doi: […]
March 21, 2021
Yucheng Gao, Yueming Zhu, Elizabeth L Tran, Valerie Tokars, Angela E Dean, Songhua Quan, David Gius Int J Biol Sci. 2021 Mar 19;17(5):1203-1216. doi: 10.7150/ijbs.51184. eCollection 2021. Abstract: Manganese superoxide dismutase (MnSOD) acetylation (Ac) has been shown to be a key post-translational modification important in the regulation of detoxification activity in various disease models. We […]