Morita M, Siddiqui N, Katsumura S, Rouya C, Larsson O, Nagashima T, Hekmatnejad B, Takahashi A, Kiyonari H, Zang M, St-Arnaud R, Oike Y, Giguère V, Topisirovic I, Okada-Hatakeyama M, Yamamoto T, Sonenberg N PNAS. 2019 Apr 16;116(16):7973-7981. doi: 10.1073/pnas.1816023116. Epub 2019 Mar 29. Abstract Whole-body metabolic homeostasis is tightly controlled by hormone-like factors with […]
Hak Joo Lee, Olga Gonzalez, Edward J Dick, Andrew Donati, Denis Feliers, Goutam Ghosh Choudhury, Corinna Ross, Manjeri Venkatachalam, Suzette D Tardif, Balakuntalam S Kasinath J Gerontol A Biol Sci Med Sci. 2019 Feb 15;74(3):315-324. doi: 10.1093/gerona/gly237. Abstract: We evaluated whether the marmoset, a nonhuman primate, can serve as a good model to study aging […]
Kelly R Reveles, Shrina Patel, Larry Forney, Corinna N Ross American Journal of Primatology. 2019 Feb;81(2):e22960. doi: 10.1002/ajp.22960. Epub 2019 Feb 25. Abstract: The gut microbiome is known to play a significant role in human health but its role in aging remains unclear. The objective of this study was to compare the gut microbiome composition […]
Matt Kaeberlein, Veronica Galvan Sci Transl Med. 2019 Jan 23;11(476). pii: eaar4289. doi: 10.1126/scitranslmed.aar4289. Abstract: The drug rapamycin has beneficial effects in a number of animal models of neurodegeneration and aging including mouse models of Alzheimer’s disease. Despite its compelling preclinical record, no clinical trials have tested rapamycin or other mTOR inhibitors in patients with […]
Cynthia L Blanco, Amalia Gastaldelli, Diana G Anzueto, Lauryn A Winter, Steven R Seidner, Donald C McCurnin, Hanyu Liang, Martin A Javors, Ralph A DeFronzo, Nicolas Musi PLoS one. 2018 Dec 12;13(12):e0208757. doi: 10.1371/journal.pone.0208757. eCollection 2018. Abstract: Premature baboons exhibit peripheral insulin resistance and impaired insulin signaling. 5′ AMP-activated protein kinase (AMPK) activation improves insulin […]
Geneva M Cunningham, Lisa C Flores, Madeline G Roman, Christie Cheng, Sara Dube, Colton Allen, Joseph M Valentine, Gene B Hubbard, Yidong Bai, Thomas L Saunders, Yuji Ikeno. GeroScience 2018 Dec;40(5-6):453-468. doi: 10.1007/s11357-018-0039-6. Epub 2018 Aug 18. Abstract To investigate the role of increased levels of thioredoxin (Trx) in both the cytosol (Trx1) and mitochondria […]
Nicolas Musi, Joseph M Valentine, Kathryn R Sickora, Eric Baeuerle, Cody S Thompson, Qiang Shen, Miranda E Orr. Aging Cell. 2018 Dec;17(6):e12840. doi: 10.1111/acel.12840. Epub 2018 Oct 11. Abstract: Tau protein accumulation is the most common pathology among degenerative brain diseases, including Alzheimer’s disease (AD), progressive supranuclear palsy (PSP), traumatic brain injury (TBI), and over […]
Joseph M Valentine, Mengyao E Li, Steven E Shoelson, Ning Zhang, Robert L Reddick, Nicolas Musi J Gerontol A Biol Sci Med Sci. 2020 Mar 9;75(4):647-653. doi: 10.1093/gerona/gly262. Abstract: Nuclear Factor (NF)κB is a transcription factor that controls immune and inflammatory signaling pathways. In skeletal muscle, NFκB has been implicated in the regulation of metabolic […]
Garrett L Cornelison, Simon A Levy, Tyler Jenson, Bess Frost Aging Cell. 2018 Nov 9:e12847. doi: 10.1111/acel.12847. Epub 2018 Nov 9. Abstract: The nucleus is a spherical dual-membrane bound organelle that encapsulates genomic DNA. In eukaryotes, messenger RNAs (mRNA) are transcribed in the nucleus and transported through nuclear pores into the cytoplasm for translation into […]
Aubrey M Sills, Joselyn M Artavia, Brian D DeRosa, Corinna N Ross, Adam B Salmon American Journal of Primatology. 2019 Feb;81(2):e22927. doi: 10.1002/ajp.22927. Epub 2018 Oct 12. Abstract: Interventions to extend lifespan and improve health with increasing age would have significant impact on a growing aged population. There are now several pharmaceutical interventions that extend […]
