Caitlyn Fastenau, Madison Bunce, Mallory Keating, Jessica Wickline, Sarah C Hopp, Kevin F Bieniek Brain Pathol. 2024 Jul;34(4):e13267. doi: 10.1111/bpa.13267. Epub 2024 May 9. Abstract: Glycosylation is the most common form of post-translational modification in the brain. Aberrant glycosylation has been observed in cerebrospinal fluid and brain tissue of Alzheimer’s disease (AD) cases, including dysregulation […]
Alisa B Nelson, Lisa S Chow, Donald R Dengel, Meixia Pan, Curtis C Hughey, Xianlin Han, Patrycja Puchalska, Peter A Crawford PLoS One. 2024 May 6;19(5):e0300037. doi: 10.1371/journal.pone.0300037. eCollection 2024. Abstract: Fatty acid esters of hydroxy fatty acid (FAHFA) are anti-diabetic and anti-inflammatory lipokines. Recently FAHFAs were also found to predict cardiorespiratory fitness in a […]
Daniel A Adekunbi, Bowen Yang, Hillary F Huber, Angelica M Riojas, Alexander J Moody, Cun Li, Michael Olivier, Peter W Nathanielsz, Geoffery D Clarke, Laura A Cox, Adam B Salmon bioRxiv [Preprint]. 2024 May 5:2024.05.02.592246. doi: 10.1101/2024.05.02.592246. Abstract: We previously demonstrated in baboons that maternal undernutrition (MUN), achieved by 70 % of control nutrition, impairs […]
Nisi Jiang, Jonathan Gelfond, Qianqian Liu, Randy Strong, James F Nelson Geroscience. 2024 Oct;46(5):4533-4541. doi: 10.1007/s11357-024-01161-9. Epub 2024 Apr 17. Abstract: The National Institute on Aging Interventions Testing Program (ITP) has so far identified 12 compounds that extend the lifespan of genetically heterogeneous mice using the log-rank test. However, the log-rank test is relatively insensitive […]
Guo Ge, Barath P Sivasubramanian, Bill D Geng, Shujie Zhao, Qing Zhou, Gang Huang, Jason C O’Connor, Robert A Clark, Senlin Li Gene Ther. 2024 May;31(5-6):324-334. doi: 10.1038/s41434-024-00451-3. Epub 2024 Apr 16. Abstract: Glial cell line-derived neurotrophic factor (GDNF) protects dopaminergic neurons in various models of Parkinson’s disease (PD). Cell-based GDNF gene delivery mitigates neurodegeneration […]
Daniel A Adekunbi, Hillary F Huber, Cun Li, Peter W Nathanielsz, Laura A Cox, Adam B Salmon Geroscience. 2024 Oct;46(5):4443-4459. doi: 10.1007/s11357-024-01155-7. Epub 2024 Apr 12. Abstract: Biological resilience, broadly defined as the ability to recover from an acute challenge and return to homeostasis, is of growing importance to the biology of aging. At the […]
Yong Ge, Changjun Yang, Mojgan Zadeh, Shane M Sprague, Yang-Ding Lin, Heetanshi Sanjay Jain, Brenden Fitzgerald Determann 2nd, William H Roth, Juan Pablo Palavicini, Jonathan Larochelle, Eduardo Candelario-Jalil, Mansour Mohamadzadeh iScience. 2024 Mar 14;27(4):109480. doi: 10.1016/j.isci.2024.109480. eCollection 2024 Apr 19. Abstract: Ischemic stroke is the second leading cause of death and disability worldwide, and efforts […]
Pataje G Prasanna, Deborah E Citrin, Jeffrey Hildesheim, Mansoor M Ahmed, Sundar Venkatachalam, Gabriela Riscuta, Dan Xi, Guangrong Zheng, Jan van Deursen, Jorg Goronzy, Stephen J Kron, Mitchell S Anscher, Norman E Sharpless, Judith Campisi, Stephen L Brown, Laura J Niedernhofer, Ana O’Loghlen, Alexandros G Georgakilas, Francois Paris, David Gius, David A Gewirtz, Clemens A […]
Yuji Ikeno Aging Pathobiol Ther. 2021;3(2):17-19. doi: 10.31491/apt.2021.06.056. Epub 2021 Jun 29. Abstract: After the discovery of thioredoxin as a reductant for many important enzymes in the early 1960s, biological roles of thioredoxin in pathophysiology have been examined using various species and experimental models, e.g., yeast, invertebrates, rodents, and humans. A large number of studies […]
