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Pharmacology and Drug Design Core



The services and expertise we provide help investigators at all stages of their careers, from early stage to senior scientists. Using these services can provide preliminary data or cost-effective access to expertise. Core services can also be crucial to established investigators new to aging research, to overcome bottlenecks and to encourage new areas of research.
 

Core Services Offered:
  • Developing and validating bioanalytical assays for drugs and small molecules.
  • Designing and creating usable, effective dosage forms.
  • Measuring and confirming concentrations and stability of drugs in dosage forms.
  • Quantifying and confirming drug concentrations in blood and tissues.
  • Informing investigators on the process of dosage form development.
  • Recommending pharmacologic approaches, such as level/timing of doses in studies.
  • Proposing and justifying pharmacokinetic experiments if needed
  • Assisting in interpretation of data and preparation of papers and grants

 
Please click on the BPAL logo below for more information about our services, facilities, and equipment.

Biochemical Pharmacology Analytical Lab

Drug Discovery Services Offered:
  • Gerotherapeutic target identification and validation by RNAi and CRISPR KO screening
  • Druggable site identification by structural biology guided and computer-aided drug discovery
  • High throughput screening for new gerotherapeutics
  • Virtual screening for new gerotherapeutics
  • Development of protein targeting chimeras (PROTACs) for undruggable or difficult druggable targets
  • Hit-to-lead optimization of new gerotherapeutics by artificial intelligence-based analog searching

 
Target identification and validation facility and resources (https://gccri.uthscsa.edu/services/tdc/)

Drug discovery facilities and resources (https://cidd.uthscsa.edu/)

Center for Innovative Drug Discovery