Aging Animal Models and Longevity Assessment Core Publishes First Study with Oral Form of Rapamycin

November 25, 2014

The Aging Animal Models and Longevity Assessment Core published the first study to demonstrate that long-term oral, daily dosing with the anti-aging drug, rapamycin, is well tolerated in a non-human primate and modulates mTOR signaling. The ability to rapidly and reliably dose socially housed marmosets with an oral form of rapamycin that is well tolerated […]

Southwest Reasearch Institute Collaborates with the San Antonio Nathan Shock Center to Test α-Linoleic Acid (ALA) and its Effects on Aging

November 9, 2014

Alfred Fisher, M.D., Ph.D. A research group at Southwest Research Institute was interested in testing whether α-linoleic acid (ALA) had effects on aging based upon their experiments showing that (1) the treatment of animals with ALA protected neurons against damage from neurotoxic agents, and (2) prior work showing that ALA reduced inflammation and increased mitochondrial […]

Administrative and Program Enrichment Core Statistical Component

October 31, 2014

Jonathan Gelfond, M.D., Ph.D. The statistical component of the administration core is lead by Dr. Jonathan Gelfond and has contributed to multi-institutional collaborations and has projected its capability to the aging research community through analytical tools. The efforts include an in-depth analysis of rapamycin and caloric restriction effects on the mouse liver transcriptome such as […]

Introducing Our Newest Core: Bioanalytical Pharmacology and Drug Evaluation Core

October 31, 2014

The important and significant discovery in 2009 that the drug rapamycin extended longevity in a mammal (BL6 mice) and that drugs can be used to study mechanisms of aging has required the development of early stage research design procedures to quantify the drug in lab chow, blood, and tissues to confirm the adequate delivery to […]

Examining Various Aspects of Age-related Changes in Physiology in the Naked Mole-Rat

October 31, 2014

Dr. Rochelle Buffenstein of the Aging Animal Models and Longevity Assessment Core and her team have continued to examine various aspects of age-related changes in physiology in the naked mole-rat and within the past 5 years have discovered some significant breakthroughs. Bone quality In this regard we have examined age-related changes in bone quality (Pinto […]

Research Development Core – 2014-2015 Pilot Grant Awardees

September 1, 2014

The Research Development Core would like to congratulate our 2014-2015 Pilot Grant Awardees! Martin Paukert, M.D. and Pei Wang, Ph.D. have been selected to receive Pilot Grants from the San Antonio Nathan Shock Center Research Development Core. Dr. Martin Paukert‘s research interests include studying the role of neuron-astroglia interaction in neuromodulation. A particular focus of […]