Publications

p53 and rapamycin are additive.

June 30, 2015

Christy B, Demaria M, Campisi J, Huang J, Jones D, Dodds SG, Williams C, Hubbard G, Livi CB, Gao X, Weintraub S, Curiel T, Sharp ZD, Hasty P. Oncotarget. 2015 Jun 30;6(18):15802-13. doi: 10.18632/oncotarget.4602. Abstract: Mechanistic target of rapamycin (mTOR) is a kinase found in a complex (mTORC1) that enables macromolecular synthesis and cell growth […]

Obesity-induced oxidative stress, accelerated functional decline with age and increased mortality in mice

June 15, 2015

Zhang Y, Fischer KE, Soto V, Liu Y, Sosnowska D, Richardson A, Salmon AB. Arch Biochem Biophys. 2015 Jun 15;576:39-48. doi: 10.1016/j.abb.2014.12.018. Epub 2015 Jan 3. Abstract Obesity is a serious chronic disease that increases the risk of numerous co-morbidities including metabolic syndrome, cardiovascular disease and cancer as well as increases risk of mortality, leading […]

The paradoxical role of thioredoxin on oxidative stress and aging.

June 15, 2015

Cunningham GM, Roman MG, Flores LC, Hubbard GB, Salmon AB, Zhang Y, Gelfond J, Ikeno Y. Arch Biochem Biophys. 2015 Jun 15;576:32-8. doi: 10.1016/j.abb.2015.02.025. Epub 2015 Feb 26. Abstract: In spite of intensive study, there is still controversy about the free radical or oxidative stress theory of aging, particularly in mammals. Our laboratory has conducted […]