Home » Archives for April 2020
Publications
Rapamycin rejuvenates oral health in aging mice
April 28, 2020
Jonathan Y An, Kristopher A Kerns, Andrew Ouellette, Laura Robinson, H Douglas Morris, Catherine Kaczorowski, So-Il Park, Title Mekvanich, Alex Kang, Jeffrey S McLean, Timothy C Cox, Matt Kaeberlein Elife. 2020 Apr 28:9:e54318. doi: 10.7554/eLife.54318. Abstract: Periodontal disease is an age-associated disorder clinically defined by periodontal bone loss, inflammation of the specialized tissues that surround […]
Hepatic Choline Transport Is Inhibited During Fatty Acid-Induced Lipotoxicity and Obesity
April 10, 2020
Conor O’Dwyer, Rebecca Yaworski, Sakie Katsumura, Peyman Ghorbani, Kaelan Gobeil Odai, Julia R C Nunes, Nicholas D LeBlond, Sabrin Sanjana, Tyler T K Smith, Shauna Han, Kaitlyn D Margison, Tommy Alain, Masahiro Morita, Morgan D Fullerton Hepatol Commun. 2020 Apr 10;4(6):876-889. doi: 10.1002/hep4.1516. eCollection 2020 Jun. Abstract: Choline is an essential nutrient and a critical […]
The mitochondria-targeted peptide SS-31 binds lipid bilayers and modulates surface electrostatics as a key component of its mechanism of action
April 9, 2020
Wayne Mitchell, Emily A Ng, Jeffrey D Tamucci, Kevin J Boyd, Murugappan Sathappa, Adrian Coscia, Meixia Pan, Xianlin Han, Nicholas A Eddy, Eric R May, Hazel H Szeto, Nathan N Alder J Biol Chem. 2020 May 22;295(21):7452-7469. doi: 10.1074/jbc.RA119.012094. Epub 2020 Apr 9. Abstract: Mitochondrial dysfunction underlies many heritable diseases, acquired pathologies, and aging-related declines […]
Awakening the dark side: retrotransposon activation in neurodegenerative disorders
April 1, 2020
Elizabeth Ochoa Thomas, Gabbe Zuniga, Wenyan Sun, Bess Frost. Current Opinion in Neurobiology. 2020 Apr;61:65-72. doi: 10.1016/j.conb.2020.01.012. Epub 2020 Feb 21. Abstract: Nearly half (45%) of the human genome is composed of transposable elements, or ‘jumping genes’. Since Barbara McClintock’s original discovery of transposable elements in 1950, we have come to appreciate that transposable element […]