Sara Espinoza, MD, MSc, an Associate Professor in the Department of Medicine and the Barshop Institute, has received a $2.0 million R01 award from the NIH National Institute on Aging for the project “Metformin for Preventing Frailty in High Risk Older Adults”. The major goal of this five-year study, which originated as a SA OAIC Year 1 pilot study, is to test metformin as a novel intervention for the prevention of frailty. Dr. Espinoza proposes that diabetes/insulin resistance and inflammation are major contributors to frailty, and that the use of metformin to modulate diabetes/insulin resistance and inflammation will prevent and/or ameliorate the progression of frailty.