Pathology Core Publications

21 Jan 2015

A listing of publications from the San Antonio Nathan Shock Center Pathology Core.


Jeffrey W. Hofmann, Xiaoai Zhao, Marco De Cecco, Abigail L. Peterson, Jayameenakshi Manivannan, Gene B. Hubbard, Yuji Ikeno, Yongqing Zhang, Bin Feng, Wenbo Qi, Holly Van Remmen, Richard A. Miller, Rafael de Cabo, Haiyan Xu, Nicola Neretti and John M.Sedivy. Reduced Expression of the Proto-oncogene Myc Increases Mouse Longevity and Enhances Healthspan. Cell. doi:10.1016/j.cell.2014.12.016, 2015.


Gong Z, Kennedy O, Sun H, Wu Y, Williams GA, Klein L, Cardoso L, Matheny RW Jr, Hubbard GB, Ikeno Y, Farrar RP, Schaffler MB, Adamo ML, Muzumdar RH, Yakar S. Reductions in serum IGF-1 during aging impair health span. Aging Cell. 2014 Jun;13(3):408-18. doi: 10.1111/acel.12188. Epub 2013 Dec 30. PubMed PMID: 24341939.

Kumar, S., Dick, E.J., Bommineni, Y.R., Yang, A, Mubiru, J., Hubbard, G.B., Owston, M.A. Reovirus-associated meningoencephalomyelitis in baboons. Vet Pathol. 2014 May;51(3):641-50. doi: 10.1177/0300985813497487. Epub 2013 Jul 26. PMID: 23892376

Lorenzini, A., Salmon, A.B., Lerner, C., Torres, C., Ikeno, Y., Motch, S., McCarter, R., Sell, C. Mice producing reduced levels of insulin-like growth factor type 1 display an increase in maximum, but not mean, life span. J Gerontol A Biol Sci Med Sci. 2014 Apr;69(4):410-9. doi: 10.1093/gerona/glt108. Epub 2013 Jul 20. PMID: 23873963

Hasty, P., Livi, C.B., Dodds, S.G., Jones, D., Strong, R., Javors, M., Fischer, K.E., Sloane, L., Murthy, K., Hubbard, G., Sun, L., Hurez, V., Curiel, T.J., Sharp, Z.D. eRapa restores a normal life span in a FAP mouse model. Cancer Prev Res. 2014 Jan;7(1):169-78. doi: 10.1158/1940-6207.CAPR-13-0299. Epub 2013 Nov 26. PMID: 24282255


Ikeno Y, Hubbard GB, Lee S, Dube SM, Flores LC, Roman MG, Bartke A. Do Ames dwarf and calorie-restricted mice share common effects on age-related pathology? Pathobiol Aging Age Relat Dis. 2013 Jun 20;3. doi: 10.3402/pba.v3i0.20833. Print 2013. PubMed PMID: 23799173; PubMed Central PMCID: PMC3689900.

Ladiges, W., Ikeno, Y., Liggitt, D., Treuting, P.M. Pathology is a critical aspect of preclinical aging studies. Pathobiol Aging Age Relat Dis. 2013 Aug 20;3. doi: 10.3402/pba.v3i0.22451. eCollection 2013. PMID: 23970952

Zhang, Y., Ikeno, Y., Bokov, A., Gelfond, J., Jaramillo, C., Zhang, H.M., Liu, Y., Qi, W., Hubbard, G., Richardson, A., Van Remmen, H. Dietary restriction attenuates the accelerated aging phenotype of Sod1(-/-) mice. Free Radic Biol Med. 2013 Jul;60:300-6. doi: 10.1016/j.freeradbiomed.2013.02.026. Epub 2013 Feb 28. PubMed PMID: 23459073; PubMed Central PMCID: PMC3696984.

Liu Y, Qi W, Richardson A, Van Remmen H, Ikeno Y, Salmon AB. Oxidative damage associated with obesity is prevented by overexpression of CuZn- or Mn-superoxide dismutase. Biochem Biophys Res Commun. 2013 Aug 16;438(1):78-83. doi:10.1016/j.bbrc.2013.07.029. Epub 2013 Jul 18. PubMed PMID: 23872067; PubMed Central PMCID: PMC3768142.

Livi CB, Hardman RL, Christy BA, Dodds SG, Jones D, Williams C, Strong R, Bokov A, Javors MA, Ikeno Y, Hubbard G, Hasty P, Sharp ZD. Rapamycin extends lifespan of Rb1+/- mice by inhibiting neuroendocrine tumors. Aging (Albany NY). 2013 Feb;5(2):100-10. PubMed PMID: 23454836; PubMed Central PMCID: PMC3616197.

Zhang Y, Bokov A, Gelfond J, Soto V, Ikeno Y, Hubbard G, Diaz V, Sloane L, Maslin K, Treaster S, Réndon S, van Remmen H, Ward W, Javors M, Richardson A, Austad SN, Fischer K. Rapamycin extends life and health in C57BL/6 mice. J Gerontol A Biol Sci Med Sci. 2014 Feb;69(2):119-30. doi: 10.1093/gerona/glt056.Epub 2013 May 16. PubMed PMID: 23682161; PubMed Central PMCID: PMC4038246.


Flores, L.C., Ortiz, M., Dube, S., Hubbard, G.B., Lee, S., Salmon, A., Zhang, Y., Ikeno, Y. Thioredoxin, oxidative stress, cancer and aging. Longev Healthspan. 2012 Sep 3;1:4. doi: 10.1186/2046-2395-1-4. eCollection 2012. PubMed PMID: 24764510; PubMed Central PMCID: PMC3886257.

Ghosh, P.M., Shu, Z.-J., Zhu, B., Lu, Z., Ikeno, Y., Barnes, J.L., Yeh, C.-K., Zhang, B.-X., Katz, M.S., and Kamat, A. Role of b-adrenergic receptors in regulation of hepatic fat accumulation during aging. J Endocrinol. 2012 Jun;213(3):251-61. doi: 10.1530/JOE-11-0406. Epub 2012 Mar 28. PMID: 22457517

Salmon AB, Flores LC, Li Y, Van Remmen H, Richardson A, Ikeno Y. Reduction of glucose intolerance with high fat feeding is associated with anti-inflammatory effects of thioredoxin 1 overexpression in mice. Pathobiol Aging Age Relat Dis. 2012;2. doi: 10.3402/pba.v2i0.17101. Epub 2012 May 17. PubMed PMID: 22953037;PubMed Central PMCID: PMC3417639.

Sackmann-Sala L, Berryman DE, Lubbers ER, Vesel CB, Troike KM, List EO, Munn RD, Ikeno Y, Kopchick JJ. Decreased insulin sensitivity and increased oxidative damage in wasting adipose tissue depots of wild-type mice. Age (Dordr). 2012 Oct;34(5):1225-37. Epub 2011 Sep 29. PubMed PMID: 21953241; PubMed Central PMCID: PMC3448990.


Bokov AF, Garg N, Ikeno Y, Thakur S, Musi N, DeFronzo RA, Zhang N, Erickson RC, Gelfond J, Hubbard GB, Adamo ML, Richardson A. Does reduced IGF-1R signaling in Igf1r+/- mice alter aging? PLoS One. 2011;6(11):e26891. doi: 10.1371/journal.pone.0026891. Epub 2011 Nov 23. PubMed PMID: 22132081; PubMed
Central PMCID: PMC3223158.

Pérez VI, Cortez LA, Lew CM, Rodriguez M, Webb CR, Van Remmen H, Chaudhuri A, Qi W, Lee S, Bokov A, Fok W, Jones D, Richardson A, Yodoi J, Zhang Y, Tominaga K,Hubbard GB, Ikeno Y. Thioredoxin 1 overexpression extends mainly the earlier part of life span in mice. J Gerontol A Biol Sci Med Sci. 2011 Dec;66(12):1286-99. doi: 10.1093/gerona/glr125. Epub 2011 Aug 26. PubMed PMID: 21873593; PubMed Central PMCID: PMC3210956.

Samson, J.E., Mari, G., Dick, Jr E.J., Hubbard, G.B., Ferry, Jr, R.J., and Schlabritz-Loutsevitch, N.E. The morphometry of maternal-fetal oxygen exchange barrier in a baboon model of obesity. Placenta. 2011 Nov;32(11):845-51. doi: 10.1016/j.placenta.2011.07.083. Epub 2011 Aug 27. PMID: 21872927

Carter, C.S., Giovaninni, S., Seo1, D.-O., Dupree, J., Morgan, D., Chung, H.Y., Lees, H., Daniels, M., Hubbard, G.B., Lee, S., Ikeno, Y., Marzettic, E. Differential effects of enalapril and losartan on body composition and indices of muscle quality in aged male Fischer 344 x Brown Norway rats. Age. 2011 Jun;33(2):167-83. doi: 10.1007/s11357-010-9196-y. Epub 2010 Dec 14. PMID: 21153712

Moore, C.M., Dick, E.J. Jr, Hubbard, G.B., Gardner, S.M., Dunn, B.G., Brothman, A., Williams, V., Prajapati, S.I., Keller, C., and Davis, M.D. Craniorachischisis and omphalocele in a stillborn cynomolgus monkey (Macaca fascicularis). Am J Med Genet A. 2011 Jun;155A(6):1367-73. doi: 10.1002/ajmg.a.33627. Epub 2011 May 12. PMID: 21567905

Mahlke MA, Cortez LA, Ortiz MA, Rodriguez M, Uchida K, Shigenaga MK, Lee S, Zhang Y, Tominaga K, Hubbard GB, Ikeno Y. The anti-tumor effects of calorie restriction are correlated with reduced oxidative stress in ENU-induced gliomas. Pathobiol Aging Age Relat Dis. 2011;1. doi: 10.3402/pba.v1i0.7189. Epub 2011 Jun 1. PubMed PMID: 22953030; PubMed Central PMCID: PMC3417672.

Echchgadda, I., Chang, T.-H., Sabbah, A., Bakri, I., Ikeno, Y., Hubbard, G.B., Chatterjee, B., and Bose, S. Oncolytic targeting of androgen-sensitive prostate tumor by the respiratory syncytial virus (RSV): Consequences of deficient interferon-dependent anti-viral defense. BMC Cancer. 2011 Jan 28;11:43. doi: 10.1186/1471-2407-11-43. PMID: 21276246


Bitto A, Lerner C, Torres C, Roell M, Malaguti M, Perez V, Lorenzini A, Hrelia S, Ikeno Y, Matzko ME, McCarter R, Sell C. Long-term IGF-I exposure decreases autophagy and cell viability. PLoS One. 2010 Sep 7;5(9):e12592. doi:10.1371/journal.pone.0012592. PubMed PMID: 20830296; PubMed Central PMCID:PMC2935370.

Slingluff, J.L., Williams, J.T., Blau, L., Blau, A., Dick, E.J., Hubbard, G.B. Spontaneous gallbladder pathology in baboons. J Med Primatol. 2010 Apr;39(2):92-6. doi: 10.1111/j.1600-0684.2009.00387.x. Epub 2009 Sep 28. PMID: 19793177