Bioanalytical Pharmacology and Drug Evaluation Core Publications

2 Dec 2014

A listing of publications from the San Antonio Nathan Shock Center Bioanalytical Pharmacology and Drug Evaluation Core.


P Hasty, CB Livi, SG Dodds, D Jones, R Strong, M Javors, KE Fischer, L Sloane, K Murthy, G Hubbard, L Sun, V Hurez, TJ Curiel, ZD Sharp. eRapa restores normal life span in a FAP mouse model. Cancer Prevention Research, in press, 2014.

Tardif S, Ross C, Bergman P, Fernandez E, Javors M, Salmon A, Spross J, Strong R, Richardson A. Testing Efficacy of Administration of the Antiaging Drug Rapamycin in a Nonhuman Primate, the Common Marmoset. Journal Gerontology A Biol Sci Med Sci 2014; PMID: 25038772

RA Miller, DE Harrison, CM Astle, E Fernandez, K Flurkey, M Han, MA Javors, X Li, NL Nadon, JF Nelson, S Pletcher, AB Salmon, ZD Sharp, S Van Roekel, L Winkleman, R Strong. Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction. Aging Cell 13:468-77, 2014 (PMID: 24341993).

Fok WC, Chen Y, Bokov A, Zhang Y, Salmon AB, Diaz V, Javors M, Wood WH, Zhang Y, Becker KG, Pérez VI, Richardson A. Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome. PLoS One 2014;9(1):e83988. doi: 10.1371/journal.pone.0083988. eCollection 2014. PMID: 24409289 PMCID: PMC3883653.

WC Fok, A Bokov, J Gelfond, Z Yu, M Doderer, Y Chen, M Javors, WH Wood, Y Zhang, KG Becker, A Richardson, VI Pérez. Combined treatment of rapamycin and dietary restriction have a larger effect on the transcriptome and metabolome of liver. Aging Cell 13:311-319, 2014 (PMID: 24304444).

Blanchard OL, Friesenhahn G, Javors MA, Smoliga JM. Development of a lozenge for oral transmucosal delivery of trans-resveratrol in humans: proof of concept. PLoS One 2014;9(2):e90131. doi: 0.1371/journal.pone.0090131. eCollection 2014. PMID: 24587240 PMCID: PMC3935991.

DE Harrison, R Strong, DB Allison, BN Ames, CM Astle, H Atamna, E Fernandez, K Flurkey, MA Javors, NL Nadon, JF Nelson, S Pletcher, JW Simpkins, D Smith, JE Wilkinson, RA Miller. Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males. Aging Cell 13:273-282, 2014 (PMID: 24245565).


Y Fang, R Westbrook, C Hill, RK Boparai, O Arum, A Spong, F Wang, MA Javors, J Chen, LY Sun, A Bartke. Duration of rapamycin treatment has differential effects on metabolism in mice. Cell Metabolism 17:456-462, 2013 (PMID: 23473038).

R Strong, RA Miller, CM Astle, JA Baur, R de Cabo, E Fernandez, W Guo, M Javors, JL Kirkland, JF Nelson, DA Sinclair, B Teter, D Williams, N Zaveri, NL Nadon, and DE Harrison. Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium chain triglyceride oil on lifespan of genetically heterogeneous mice. Journal of Gerontology A: Biological Sciences 68:6-16, 2013 (PMID: 22451473).

Lin AL, Zheng W, Halloran JJ, Burbank RR, Hussong SA, Hart MJ, Javors M, Shih YY, Muir E, Solano Fonseca R, Strong R, Richardson AG, Lechleiter JD, Fox PT, Galvan V. Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer’s disease. Journal Cerebral Blood Flow Metabolism 2013;33(9):1412-21. doi: 10.1038/jcbfm.2013.82. Epub 2013 Jun 26. PMID: 23801246 PMCID: PMC3764385.

CB Livi, RL Hardman, BA Christy, SG Dodds, D Jones, C Williams, R Strong, A Bokov, MA Javors, Y Ikeno, G Hubbard, P Hasty, ZD Sharp. Rapamycin extends life span of Rb1+/- mice by inhibiting neuroendocrine tumors. Aging 5:100-110, 2013 (PMID: 23454836).


Majumder S, Caccamo A, Medina DX, Benavides AD, Javors MA, Kraig E, Strong R, Richardson A, Oddo S. Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling. Aging Cell 2012;11(2):326-35. doi: 10.1111/j.1474-9726.2011.00791.x. Epub 2012 Feb 1. PMID: 22212527.