Aging Animal Models and Longevity Assessment Core Naked Mole-Rat Publications

18 Dec 2014

A listing of publications with focus on Naked Mole-Rats and their tissues from the San Antonio Nathan Shock Center Aging Animal Models and Longevity Assessment Core.


Keane M, Craig T, Alföldi J, Berlin AM, Johnson J, Seluanov A, Gorbunova V, Di Palma F, Lindblad-Toh K, Church GM, de Magalhães JP. The Naked Mole Rat Genome Resource: facilitating analyses of cancer and longevity-related adaptations. Bioinformatics. 2014 Dec 15;30(24):3558-60. doi: 10.1093/bioinformatics/btu579. Epub 2014 Aug 28. PubMed PMID: 25172923; PubMed Central PMCID: PMC4253829.

Fang X, Seim I, Huang Z, Gerashchenko MV, Xiong Z, Turanov AA, Zhu Y, Lobanov AV, Fan D, Yim SH, Yao X, Ma S, Yang L, Lee SG, Kim EB, Bronson RT, Šumbera R, Buffenstein R, Zhou X, Krogh A, Park TJ, Zhang G, Wang J, Gladyshev VN. Adaptations to a subterranean environment and longevity revealed by the analysis of mole rat genomes. Cell Rep. 2014 Sep 11;8(5):1354-64. doi: 10.1016/j.celrep.2014.07.030. Epub 2014 Aug 28. PubMed PMID: 25176646.

Grimes KM, Reddy AK, Lindsey ML, Buffenstein R. And the beat goes on: maintained cardiovascular function during aging in the longest-lived rodent, the naked mole-rat. Am J Physiol Heart Circ Physiol. 2014 Aug 1;307(3):H284-91. doi: 10.1152/ajpheart.00305.2014. Epub 2014 Jun 6. PubMed PMID: 24906918; PubMed Central PMCID: PMC4121653.

Larson J, Drew KL, Folkow LP, Milton SL, Park TJ. No oxygen? No problem! Intrinsic brain tolerance to hypoxia in vertebrates. J Exp Biol. 2014 Apr 1;217(Pt 7):1024-39. doi: 10.1242/jeb.085381. Review. PubMed PMID: 24671961; PubMed Central PMCID: PMC3966918.

Edrey YH, Oddo S, Cornelius C, Caccamo A, Calabrese V, Buffenstein R. Oxidative damage and amyloid-β metabolism in brain regions of the longest-lived rodents. J Neurosci Res. 2014 Feb;92(2):195-205. doi: 10.1002/jnr.23320. Epub 2013 Nov 22. PubMed PMID: 24273049.

Ables, G. P., H. M. Brown-Borg, et al. “The first international mini-symposium on methionine restriction and lifespan.” Frontiers in genetics 2014;5: 122. PMID 24847356

Tupal, S., M. A. Rieger, et al “Testing the role of preBotzinger Complex somatostatin neurons in respiratory and vocal behaviors.” The European journal of neuroscience 2014;40(7): 3067-3077. PMID 25040660


Edrey YH, Medina DX, Gaczynska M, Osmulski PA, Oddo S, Caccamo A, Buffenstein R. Amyloid beta and the longest-lived rodent: the naked mole-rat as a model for natural protection from Alzheimer’s disease. Neurobiol Aging. 2013 Oct;34(10):2352-60. doi: 10.1016/j.neurobiolaging.2013.03.032. Epub 2013 Apr 22.
PubMed PMID: 23618870.

Lewis KN, Andziak B, Yang T, Buffenstein R. The naked mole-rat response to oxidative stress: just deal with it. Antioxid Redox Signal. 2013 Oct 20;19(12):1388-99. doi: 10.1089/ars.2012.4911. Epub 2012 Dec 7. Review. PubMedPMID: 23025341; PubMed Central PMCID: PMC3791056.

Hamilton RT, Bhattacharya A, Walsh ME, Shi Y, Wei R, Zhang Y, Rodriguez KA, Buffenstein R, Chaudhuri AR, Van Remmen H. Elevated protein carbonylation, and misfolding in sciatic nerve from db/db and Sod1(-/-) mice: plausible link between oxidative stress and demyelination. PLoS One. 2013 Jun 4;8(6):e65725. doi: 10.1371/journal.pone.0065725. Print 2013. PubMed PMID: 23750273; PubMed Central PMCID: PMC3672154.

De Waal EM, Liang H, Pierce A, Hamilton RT, Buffenstein R, Chaudhuri AR. Elevated protein carbonylation and oxidative stress do not affect protein structure and function in the long-living naked-mole rat: a proteomic approach. Biochem Biophys Res Commun. 2013 May 17;434(4):815-9. doi: 10.1016/j.bbrc.2013.04.019. Epub 2013 Apr 22. PubMed PMID: 23618867.

Shi Y, Pulliam DA, Liu Y, Hamilton RT, Jernigan AL, Bhattacharya A, Sloane LB, Qi W, Chaudhuri A, Buffenstein R, Ungvari Z, Austad SN, Van Remmen H. Reduced mitochondrial ROS, enhanced antioxidant defense, and distinct age-related changes in oxidative damage in muscles of long-lived Peromyscus leucopus. Am J Physiol Regul Integr Comp Physiol. 2013 Mar 1;304(5):R343-55. doi: 10.1152/ajpregu.00139.2012. Epub 2013 Jan 16. PubMed PMID: 23325454; PubMed Central PMCID: PMC4116415.


LaVinka PC, Park TJ. Blunted behavioral and c Fos responses to acidic fumes in the African naked mole-rat. PLoS One. 2012;7(9):e45060. doi: 10.1371/journal.pone.0045060. Epub 2012 Sep 17. PubMed PMID: 23028761; PubMed Central PMCID: PMC3444467.

St John Smith E, Purfürst B, Grigoryan T, Park TJ, Bennett NC, Lewin GR. Specific paucity of unmyelinated C-fibers in cutaneous peripheral nerves of the African naked-mole rat: comparative analysis using six species of Bathyergidae. J Comp Neurol. 2012 Aug 15;520(12):2785-803. doi: 10.1002/cne.23133. PubMed PMID:
22528859; PubMed Central PMCID: PMC3410526.

Rodriguez KA, Edrey YH, Osmulski P, Gaczynska M, Buffenstein R. Altered composition of liver proteasome assemblies contributes to enhanced proteasome activity in the exceptionally long-lived naked mole-rat. PLoS One. 2012;7(5):e35890. doi: 10.1371/journal.pone.0035890. Epub 2012 May 2. PubMed
PMID: 22567116; PubMed Central PMCID: PMC3342291.

Lewis KN, Mele J, Hornsby PJ, Buffenstein R. Stress resistance in the naked mole-rat: the bare essentials – a mini-review. Gerontology. 2012;58(5):453-62. doi: 10.1159/000335966. Epub 2012 May 10. PubMed PMID: 22572398.

Grimes KM, Lindsey ML, Gelfond JA, Buffenstein R. Getting to the heart of the matter: age-related changes in diastolic heart function in the longest-lived rodent, the naked mole rat. J Gerontol A Biol Sci Med Sci. 2012 Apr;67(4):384-94. doi: 10.1093/gerona/glr222. Epub 2012 Feb 24. PubMed PMID: 22367435; PubMed Central PMCID: PMC3309875.

Edrey YH, Casper D, Huchon D, Mele J, Gelfond JA, Kristan DM, Nevo E, Buffenstein R. Sustained high levels of neuregulin-1 in the longest-lived rodents; a key determinant of rodent longevity. Aging Cell. 2012 Apr;11(2):213-22. doi: 10.1111/j.1474-9726.2011.00772.x. Epub 2011 Dec 29. PubMed PMID: 22103690.

Peterson BL, Larson J, Buffenstein R, Park TJ, Fall CP. Blunted neuronal calcium response to hypoxia in naked mole-rat hippocampus. PLoS One. 2012;7(2):e31568. doi: 10.1371/journal.pone.0031568. Epub 2012 Feb 21. PubMed PMID: 22363676; PubMed Central PMCID: PMC3283646.

Peterson BL, Park TJ, Larson J. Adult naked mole-rat brain retains the NMDA receptor subunit GluN2D associated with hypoxia tolerance in neonatal mammals. Neurosci Lett. 2012 Jan 11;506(2):342-5. doi: 10.1016/j.neulet.2011.11.042. Epub 2011 Dec 3. PubMed PMID: 22155615.


Malinouski M, Kehr S, Finney L, Vogt S, Carlson BA, Seravalli J, Jin R, Handy DE, Park TJ, Loscalzo J, Hatfield DL, Gladyshev VN. High-resolution imaging of selenium in kidneys: a localized selenium pool associated with glutathione peroxidase 3. Antioxid Redox Signal. 2012 Feb 1;16(3):185-92. doi: 10.1089/ars.2011.3997. Epub 2011 Nov 22. PubMed PMID: 21854231; PubMed Central PMCID: PMC3234661.

Yu C, Li Y, Holmes A, Szafranski K, Faulkes CG, Coen CW, Buffenstein R, Platzer M, de Magalhães JP, Church GM. RNA sequencing reveals differential expression of mitochondrial and oxidation reduction genes in the long-lived naked mole-rat when compared to mice. PLoS One. 2011;6(11):e26729. doi: 10.1371/journal.pone.0026729. Epub 2011 Nov 3. PubMed PMID: 22073188; PubMed Central PMCID: PMC3207814.

Kim EB, Fang X, Fushan AA, Huang Z, Lobanov AV, Han L, Marino SM, Sun X, Turanov AA, Yang P, Yim SH, Zhao X, Kasaikina MV, Stoletzki N, Peng C, Polak P, Xiong Z, Kiezun A, Zhu Y, Chen Y, Kryukov GV, Zhang Q, Peshkin L, Yang L, Bronson RT, Buffenstein R, Wang B, Han C, Li Q, Chen L, Zhao W, Sunyaev SR, Park TJ,
Zhang G, Wang J, Gladyshev VN. Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Nature. 2011 Oct 12;479(7372):223-7. doi: 10.1038/nature10533. PubMed PMID: 21993625; PubMed Central PMCID: PMC3319411.

Bhattacharya A, Leonard S, Tardif S, Buffenstein R, Fischer KE, Richardson A,  Austad SN, Chaudhuri AR. Attenuation of liver insoluble protein carbonyls: indicator of a longevity determinant? Aging Cell. 2011 Aug;10(4):720-3. doi: 10.1111/j.1474-9726.2011.00712.x. Epub 2011 May 6. PubMed PMID: 21463461; PubMed Central PMCID: PMC3766365.

Kasaikina MV, Lobanov AV, Malinouski MY, Lee BC, Seravalli J, Fomenko DE, Turanov AA, Finney L, Vogt S, Park TJ, Miller RA, Hatfield DL, Gladyshev VN. Reduced utilization of selenium by naked mole rats due to a specific defect in GPx1 expression. J Biol Chem. 2011 May 13;286(19):17005-14. doi: 10.1074/jbc.M110.216267. Epub 2011 Mar 3. PubMed PMID: 21372135; PubMed Central PMCID: PMC3089545.

Rodriguez KA, Wywial E, Perez VI, Lambert AJ, Edrey YH, Lewis KN, Grimes K, Lindsey ML, Brand MD, Buffenstein R. Walking the oxidative stress tightrope: a perspective from the naked mole-rat, the longest-living rodent. Curr Pharm Des. 2011;17(22):2290-307. Review. PubMed PMID: 21736541; PubMed Central PMCID: PMC3980719.

Edrey YH, Hanes M, Pinto M, Mele J, Buffenstein R. Successful aging and sustained good health in the naked mole rat: a long-lived mammalian model for biogerontology and biomedical research. ILAR J. 2011;52(1):41-53. PubMed PMID: 21411857.

Edrey YH, Park TJ, Kang H, Biney A, Buffenstein R. Endocrine function and neurobiology of the longest-living rodent, the naked mole-rat. Exp Gerontol. 2011 Feb-Mar;46(2-3):116-23. doi: 10.1016/j.exger.2010.09.005. Epub 2010 Oct 1. Review. PubMed PMID: 20888895.

Gladyshev, V. N., G. Zhang, et al. “The naked mole rat genome: understanding aging through genome analysis.” Aging 2011;3(12): 1124. PMID 22199030

Smith, E. S., D. Omerbasic, et al. (2011). “The molecular basis of acid insensitivity in the African naked mole-rat.” Science 334(6062): 1557-1560. PMID 22174253


Brand A, Smith ES, Lewin GR, Park TJ. Functional neurokinin and NMDA receptor activity in an animal naturally lacking substance P: the naked mole-rat. PLoS One. 2010 Dec 21;5(12):e15162. doi: 10.1371/journal.pone.0015162. PubMed PMID: 21200438; PubMed Central PMCID: PMC3006196.

Lewis KN, Mele J, Hayes JD, Buffenstein R. Nrf2, a guardian of healthspan and gatekeeper of species longevity. Integr Comp Biol. 2010 Nov;50(5):829-43. doi: 10.1093/icb/icq034. Epub 2010 May 6. PubMed PMID: 21031035; PubMed Central PMCID: PMC2965188.

Shi Y, Buffenstein R, Pulliam DA, Van Remmen H. Comparative studies of oxidative stress and mitochondrial function in aging. Integr Comp Biol. 2010 Nov;50(5):869-79. doi: 10.1093/icb/icq079. Epub 2010 Jul 2. PubMed PMID: 21558246.

Liang S, Mele J, Wu Y, Buffenstein R, Hornsby PJ. Resistance to experimental tumorigenesis in cells of a long-lived mammal, the naked mole-rat (Heterocephalus glaber). Aging Cell. 2010 Aug;9(4):626-35. doi: 10.1111/j.1474-9726.2010.00588.x. Epub 2010 Jun 9. PubMed PMID: 20550519; PubMed Central PMCID: PMC3743245.

Smith ES, Blass GR, Lewin GR, Park TJ. Absence of histamine-induced itch in the African naked mole-rat and “rescue” by Substance P. Mol Pain. 2010 May 24;6:29. doi: 10.1186/1744-8069-6-29. PubMed PMID: 20497578; PubMed Central PMCID: PMC2886013.

Pinto M, Jepsen KJ, Terranova CJ, Buffenstein R. Lack of sexual dimorphism in femora of the eusocial and hypogonadic naked mole-rat: a novel animal model for the study of delayed puberty on the skeletal system. Bone. 2010 Jan;46(1):112-20. doi: 10.1016/j.bone.2009.08.060. Epub 2009 Sep 15. PubMed PMID: 19761882.


Larson J, Park TJ. Extreme hypoxia tolerance of naked mole-rat brain. Neuroreport. 2009 Dec 9;20(18):1634-7. doi: 10.1097/WNR.0b013e32833370cf. PubMed PMID: 19907351.

Pérez VI, Buffenstein R, Masamsetti V, Leonard S, Salmon AB, Mele J, Andziak B, Yang T, Edrey Y, Friguet B, Ward W, Richardson A, Chaudhuri A. Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3059-64. doi: 10.1073/pnas.0809620106. Epub 2009 Feb 17. PubMed PMID: 19223593; PubMed Central PMCID: PMC2651236.

Buffenstein R, Pinto M. Endocrine function in naturally long-living small mammals. Mol Cell Endocrinol. 2009 Feb 5;299(1):101-11. doi: 10.1016/j.mce.2008.04.021. Epub 2008 Jul 15. Review. PubMed PMID: 18674586.