Aging Animal Models and Longevity Assessment Core Publications

16 Jan 2015

A listing of publications from the San Antonio Nathan Shock Center Aging Animal Models and Longevity Assessment Core.


Zhang Y, Fischer KE, Soto V, Liu Y, Sosnowska D, Richardson A, Salmon AB. Obesity-induced oxidative stress, accelerated functional decline with age and increased mortality in mice. Arch Biochem Biophys. 2015 Jan 3. pii: S0003-9861(14)00443-3. doi: 10.1016/ [Epub ahead of print] PubMed PMID: 25558793.


Fok WC, Bokov A, Gelfond J, Yu Z, Zhang YQ, Doderer M,et al. Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver. Aging Cell. 2014;13(2):311-9. PMID: 24304444; PMCID: PMC3989927.

Fok WC, Chen YD, Bokov A, Zhang YQ, Salmon AB, Diaz V,et al. Mice Fed Rapamycin Have an Increase in Lifespan Associated with Major Changes in the Liver Transcriptome. Plos One. 2014;9(1). PMID: 24409289; PMCID: PMC3883653.

Fok WC, Livi C, Bokov A, Yu Z, Chen YD, Richardson A, et al. Short-term rapamycin treatment in mice has few effects on the transcriptome of white adipose tissue compared to dietary restriction. Mech Ageing Dev. 2014;140:23-9. PMID: 25075714; PMCID: PMC4167584.

Harrison DE, Strong R, Allison DB, Ames BN, Astle CM, Atamna H, Fernandez E, Flurkey K, Javors MA, Nadon NL, Nelson JF, Pletcher S, Simpkins JW, Smith D, Wilkinson JE, Miller RA. Acarbose, 17-alpha-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males. Aging cell. 2014;13(2):273-82. PMID: 24245565 PMCID: PMC3954939.

Hasty, P., Livi, C.B., Dodds, S.G., Jones, D., Strong, R., Javors, M., Fischer, K.E., Sloane, L., Murthy, K., Hubbard, G., Sun, L., Hurez, V., Curiel, T.J., Sharp, Z.D. eRapa restores a normal life span in a FAP mouse model. Cancer Prev Res. 2014 Jan;7(1):169-78.. PMID: 24282255

Miller RA, Harrison DE, Astle CM, Fernandez E, Flurkey K, Han M, Javors MA, Li X, Nadon NL, Nelson JF, Pletcher S, Salmon AB, Sharp ZD, Van Roekel S, Winkleman L, Strong R. Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction. Aging cell. 2014;13:468-477. PMID: 24341993. PMCID: PMC4032600

Zhang Y, Bokov A, Gelfond J, Soto V, Ikeno Y, Hubbard G, Diaz V, Sloane L, Maslin K, Treaster S, Réndon S, van Remmen H, Ward W, Javors M, Richardson A, Austad SN, Fischer K. Rapamycin extends life and health in C57BL/6 mice. J Gerontol A Biol Sci Med Sci. 2014 Feb;69(2):119-30. PubMed PMID: 23682161; PMCID: PMC4038246.


Deepa SS, Walsh ME, Hamilton RT, Pulliam D, Shi Y, Hill S, Li Y, Van Remmen H. Rapamycin Modulates Markers of Mitochondrial Biogenesis and Fatty Acid Oxidation in the Adipose Tissue of db/db Mice. J Biochem Pharmacol Res. 2013 Jun;1(2):114-123. PMID: 24010023

Liao CY, Johnson TE, Nelson JF. Genetic variation in responses to dietary restriction–an unbiased tool for hypothesis testing. Exp Gerontol 2013; 48:1025-1029. PMID: 23562825.

Lin AL, Pulliam DA, Deepa SS, Halloran JJ, Hussong SA,Burbank RR, et al. Decreased in vitro mitochondrial function is associated with enhanced brain metabolism, blood flow, and memory in Surf1-deficient mice. J Cerebr Blood F Met. 2013;33(10):1605-11. PMID: 23838831; PMCID: PMC3790931.

Liu Y, Qi W, Richardson A, Van Remmen H, Ikeno Y, Salmon AB. Oxidative damage associated with obesity is prevented by overexpression of CuZn- or Mn-superoxide dismutase Biochem Biophys Res Commun. 2013 Aug 16;438(1):78-83..PMID:23872067

Livi CB, Hardman RL, Christy BA, Dodds SG, Jones D, Williams C, Strong R, Bokov A, Javors MA, Ikeno Y, Hubbard G, Hasty P, Sharp ZD. Rapamycin extends life span of Rb1+/- mice by inhibiting neuroendocrine tumors.Aging (Albany NY). 2013 Feb;5(2):100-10. PMID: 23454836

Muscogiuri G, Salmon AB, Aguayo-Mazzucato C, Li M, Balas B, Guardado-Mendoza R, Giaccari A, Reddick RL, Reyna SM, Weir G, Defronzo RA, Van Remmen H, Musi N. Genetic disruption of SOD1 gene causes glucose intolerance and impairs β-cell function. Diabetes. 2013 Dec;62(12):4201-7. PMID:24009256

Strong R, Miller RA, Astle CM, Baur JA, de Cabo R, Fernandez E, Guo W, Javors M, Kirkland JL, Nelson JF, Sinclair DA, Teter B, Williams D, Zaveri N, Nadon NL, Harrison DE. Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci. 2013 Jan;68(1):6-16. doi: 10.1093/gerona/gls070. Epub 2012 Mar 26.PMID:22451473

Zhang YQ, Ikeno Y, Bokov A, Gelfond J, Jaramillo C, Zhang HM, et al. Dietary restriction attenuates the accelerated aging phenotype of Sod1(-/-) mice. Free Radical Biology and Medicine. 2013;60:300-6. PMID: 23459073; PMCID: PMC3696984.


Bhattacharya A, Bokov A, Muller FL, Jernigan AL, Maslin K, Diaz V, et al. Dietary restriction but not rapamycin extends disease onset and survival of the H46R/H48Q mouse model of ALS. Neurobiol Aging. 2012;33(8):1829-32. PMID: 21763036.

Flores, L.C., Ortiz, M., Dube, S., Hubbard, G.B., Lee, S., Salmon, A., Zhang, Y., Ikeno, Y. Thioredoxin, oxidative stress, cancer and aging. Longev Healthspan. 2012 Sep 3;1:4. doi: 10.1186/2046-2395-1-4. eCollection 2012. PubMed PMID: 24764510; PubMed Central PMCID: PMC3886257.

Jang YC, Liu Y, Hayworth CR, Bhattacharya A, Lustgarten MS, Muller FL, Chaudhuri A, Qi W, Li Y, Huang JY, Verdin E, Richardson A, Van Remmen H. Dietary restriction attenuates age-associated muscle atrophy by lowering oxidative stress in mice even in complete absence of CuZnSOD. Aging Cell. 2012 Oct;11(5):770-82. PMID: 22672615

Majumder S, Caccamo A, Medina DX, Benavides AD, Javors MA, Kraig E,Strong R, Richardson A, Oddo S. Lifelong rapamycin administration ameliorates age dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling. Aging Cell. 2012 Apr;11(2):326-35. PubMed PMID: 22212527; PubMed Central PMCID: PMC330646

Nelson JF, Strong R, Bokov A, Diaz V, Ward W, Probing the Relationship Between insulin Sensitivity and Longevity Using Genetically Modified Mice J Gerontol A Biol Sci Med Sci. 2012; 67:1332-8, PMID:23089336. PMCID: PMC3670160

Salmon, A.B., Flores, L.C., Li, Y., Van Remmen, H., Richardson, A., Ikeno, Y. Reduction of glucose intolerance with high fat feeding is associated with anti-inflammatory effects of thioredoxin 1 overexpression in mice. Pathobiol Aging Age Relat Dis. 2012;2. doi: 10.3402/pba.v2i0.17101. Epub 2012 May 17. PubMed PMID: 22953037; PubMed Central PMCID: PMC3417639.

Sataranatarajan K, Feliers D, Mariappan MM, Lee HJ, Lee MJ, Day RT, Yalamanchili HB, Choudhury GG, Barnes JL, Van Remmen H, Richardson A, Kasinath BS. Molecular events in matrix protein metabolism in the aging kidney. Aging Cell. 2012 Dec;11(6):1065-73. PMID: 23020145

Charchaflieh J, Labaze GI, Li P, Van Remmen H, Lee H, Stutz H, Richardson A, Emanuel A, Zhang M. Overexpression of human SOD1 improves survival of mice susceptible to endotoxic shock.J Inflamm Res. 2012;5:51-8. PMID: 22879777

Wey, M.C-Y., Fernandez, E., Martinez, P.A. Sullivan, Goldstein, D. S. and Strong, R. Nigrostriatal Neurodegeneration and Impaired Motor Function in Mice Lacking Cytosolic and Mitochondrial Aldehyde Dehydrogenases: Implications for Parkinson’s Disease. PLoS One, 7(2): e31522, 2012. PMID: 22384032; PMCID: PMC3284575.

Yoo SE, Chen L, Na R, Liu Y, Rios C, Van Remmen H, Richardson A, Ran Q. Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain. Free Radic Biol Med. 2012 May 1;52(9):1820-7. PMID: 22401858


Bokov AF, Garg N, Ikeno Y, Thakur S, Musi N, DeFronzo RA, et al. Does Reduced IGF-1R Signaling in Igf1r(+/-) Mice Alter Aging? Plos One. 2011;6(11). PMID: 22132081; PMCID: PMC3223158.

Liang HY, Ward WF, Jang YC, Bhattacharya A, Bokov AF,Li Y, et al. PGC-1 alpha protects neurons and alters disease progression in an amyotrophic lateral sclerosis mouse model. Muscle Nerve. 2011;44(6):947-56. PMID: 22102466.

Liao CY, Rikke BA, Johnson TE, Gelfond JA, Diaz V, Nelson JF. Fat maintenance is a predictor of the murine lifespan response to dietary restriction. Aging Cell 2011;10:629-639. PMID: 21388497

Mahlke, M., Cortez, L.A., Ortiz, M.A., Rodoriguez, M., Uchida, K., Shigenaga, M.K., Lee, S., Zhang, Y., Tominaga, K., Hubbard, G.B., and Ikeno, Y. The anti-tumor effects of CR are correlated with reduced oxidative stress in ENU-induced gliomas, Pathobiol Aging Age Relat Dis. 2011;1. doi: 10.3402/pba.v1i0.7189. Epub 2011 Jun 1. PMID: 22953030

Miller RA, Harrison DE, Astle CM, Baur JA, Boyd AR, de Cabo R, Fernandez E, Flurkey K, Javors MA, Nelson JF, Orihuela CJ, Pletcher S, Sharp ZD, Sinclair D, Starnes JW, Wilkinson JE, Nadon NL, Strong R. Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci. 2011 Feb;66(2):191-201. doi: 10.1093/gerona/glq178. Epub 2010 Oct 25. PMID:20974732

Perez VI, Cortez LA, Lew CM, Rodriguez M, Webb CR, Van Remmen H, et al. Thioredoxin 1 Overexpression Extends Mainly the Earlier Part of Life Span in Mice. J Gerontol a-Biol. 2011;66(12):1286-99. PMID: 21873593; PMCID: PMC3210956.


Liao CY, Rikke BA, Johnson TE, Diaz V, Nelson JF. Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening. Aging Cell. 2010;9(1):92-5. PMID: 19878144; PMCID: PMC3476836.