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University:

Congratulations to Bess Frost, PhD, on her recent publication in Cell Reports!

20 Jul 2020

Dr. Frost and her lab have a new paper published in Cell Reports.

Highlights
•TauR406W induces nuclear CREB depletion in neurons of the adult Drosophila brain
•Nuclear Ca2+ decreases with aging and tauopathy in the adult Drosophila brain
•Nuclear Ca2+ is depleted in iPSC-derived neurons from sporadic Alzheimer’s disease
•Pharmacologic/genetic manipulation of BK channels modify tauR406W neurotoxicity

https://doi.org/10.1016/j.celrep.2020.107900