Bioanalytical Pharmacology Core Offering Ratiometric Reporters

November 25, 2014

“The ratiometric reporter HyPer responds to levels of peroxide, such as produced by treatment of the worms with tert-butyl hydroperoxide (tBHP), in the cell by showing an increase in fluorescence when excited at 500 nm and a decrease in fluorescence when excited at 420 nm (A). These changes can be show by graphing the fluorescence […]


Aging Animal Models and Longevity Assessment Core Publishes First Study with Oral Form of Rapamycin

November 25, 2014

The Aging Animal Models and Longevity Assessment Core published the first study to demonstrate that long-term oral, daily dosing with the anti-aging drug, rapamycin, is well tolerated in a non-human primate and modulates mTOR signaling. The ability to rapidly and reliably dose socially housed marmosets with an oral form of rapamycin that is well tolerated […]


Southwest Reasearch Institute Collaborates with the San Antonio Nathan Shock Center to Test α-Linoleic Acid (ALA) and its Effects on Aging

November 9, 2014

Alfred Fisher, M.D., Ph.D. A research group at Southwest Research Institute was interested in testing whether α-linoleic acid (ALA) had effects on aging based upon their experiments showing that (1) the treatment of animals with ALA protected neurons against damage from neurotoxic agents, and (2) prior work showing that ALA reduced inflammation and increased mitochondrial […]