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Publications from the 2012-2013 Pilot Grant Awardees

25 Nov 2014

The San Antonio Nathan Shock Center Research Development Core would like to highlight the publications from the 2012-2013 Awardees of the Pilot Grant Award.

clarke William Clarke, Ph.D.

• Broselid S, Berg KA, Chavera TA, Kahn R, Clarke WP, Olde B, Leeb-Lundberg LM. G protein-coupled Receptor 30 (GPR30) Forms a Plasma Membrane Complex with Membrane-associated Guanylate Kinases (MAGUKs) and Protein Kinase A-anchoring Protein 5 (AKAP5) That Constitutively Inhibits cAMP Production. J Biol Chem. 2014 Aug 8;289(32):22117-27. doi: 10.1074/jbc.M114.566893. Epub 2014 Jun 24. PubMed PMID: 24962572; PubMed Central PMCID: PMC4139225.

• Rowan MP, Berg KA, Roberts JL, Hargreaves KM, Clarke WP. Activation of estrogen receptor α enhances bradykinin signaling in peripheral sensory neurons of female rats. J Pharmacol Exp Ther. 2014 Jun;349(3):526-32. doi: 10.1124/jpet.114.212977. Epub 2014 Apr 4. PubMed PMID: 24706985; PubMed Central PMCID: PMC4019325.

Clarke WP, Chavera TA, Silva M, Sullivan LC, Berg KA. Signalling profile differences: paliperidone versus risperidone. Br J Pharmacol. 2013 Oct;170(3):532-45. doi: 10.1111/bph.12295. PubMed PMID: 23826915; PubMed Central PMCID: PMC3791992.

SalmonA Adam Salmon, Ph.D.

• Tardif S, Ross C, Bergman P, Fernandez E, Javors M, Salmon A, Spross J, Strong R, Richardson A. Testing Efficacy of Administration of the Antiaging Drug Rapamycin in a Nonhuman Primate, the Common Marmoset. J Gerontol A Biol Sci Med Sci. 2014 Jul 19. pii: glu101. [Epub ahead of print] PubMed PMID: 25038772.

• Edrey YH, Salmon AB. Revisiting an age-old question regarding oxidative stress. Free Radic Biol Med. 2014 Jun;71:368-78. doi: 10.1016/j.freeradbiomed.2014.03.038. Epub 2014 Apr 4. PubMed PMID: 24704971; PubMed Central PMCID: PMC4049226.

• Fok WC, Chen Y, Bokov A, Zhang Y, Salmon AB, Diaz V, Javors M, Wood WH 3rd, Zhang Y, Becker KG, Pérez VI, Richardson A. Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome. PLoS One. 2014 Jan 7;9(1):e83988. doi: 10.1371/journal.pone.0083988. eCollection 2014. PubMed PMID: 24409289; PubMed Central PMCID: PMC3883653.

• Muscogiuri G, Salmon AB, Aguayo-Mazzucato C, Li M, Balas B, Guardado-Mendoza R, Giaccari A, Reddick RL, Reyna SM, Weir G, Defronzo RA, Van Remmen H, Musi N. Genetic disruption of SOD1 gene causes glucose intolerance and impairs β-cell function. Diabetes. 2013 Dec;62(12):4201-7. doi: 10.2337/db13-0314. Epub 2013 Sep 5. PubMed PMID: 24009256; PubMed Central PMCID: PMC3837066.

• Liu Y, Qi W, Richardson A, Van Remmen H, Ikeno Y, Salmon AB. Oxidative damage associated with obesity is prevented by overexpression of CuZn- or Mn-superoxide dismutase. Biochem Biophys Res Commun. 2013 Aug 16;438(1):78-83. doi:10.1016/j.bbrc.2013.07.029. Epub 2013 Jul 18. PubMed PMID: 23872067; PubMed Central PMCID: PMC3768142.

• Deepa SS, Pulliam D, Hill S, Shi Y, Walsh ME, Salmon A, Sloane L, Zhang N, Zeviani M, Viscomi C, Musi N, Van Remmen H. Improved insulin sensitivity associated with reduced mitochondrial complex IV assembly and activity. FASEB J. 2013 Apr;27(4):1371-80. doi: 10.1096/fj.12-221879. Epub 2012 Dec 14. PubMed PMID: 23241310.

• Styskal J, Nwagwu FA, Watkins YN, Liang H, Richardson A, Musi N, Salmon AB. Methionine sulfoxide reductase A affects insulin resistance by protecting insulin receptor function. Free Radic Biol Med. 2013 Mar;56:123-32. doi: 10.1016/j.freeradbiomed.2012.10.544. Epub 2012 Oct 23. PubMed PMID: 23089224; PubMed Central PMCID: PMC3578155.

Salmon AB, Flores LC, Li Y, Van Remmen H, Richardson A, Ikeno Y. Reduction of glucose intolerance with high fat feeding is associated with anti-inflammatory effects of thioredoxin 1 overexpression in mice. Pathobiol Aging Age Relat Dis. 2012;2. doi: 10.3402/pba.v2i0.17101. Epub 2012 May 17. PubMed PMID: 22953037; PubMed Central PMCID: PMC3417639.

• Fok WC, Zhang Y, Salmon AB, Bhattacharya A, Gunda R, Jones D, Ward W, Fisher K, Richardson A, Pérez VI. Short-term treatment with rapamycin and dietary restriction have overlapping and distinctive effects in young mice. J Gerontol A Biol Sci Med Sci. 2013 Feb;68(2):108-16. doi: 10.1093/gerona/gls127. Epub 2012 May 8. PubMed PMID: 22570137; PubMed Central PMCID: PMC3598360.

Salmon AB. Oxidative stress in the etiology of age-associated decline in glucose metabolism. Longev Healthspan. 2012 Nov 1;1:7. doi: 10.1186/2046-2395-1-7. eCollection 2012. Review. PubMed PMID: 24764512; PubMed Central PMCID: PMC3922939.

• Flores LC, Ortiz M, Dube S, Hubbard GB, Lee S, Salmon A, Zhang Y, Ikeno Y. Thioredoxin, oxidative stress, cancer and aging. Longev Healthspan. 2012 Sep 3;1:4. doi: 10.1186/2046-2395-1-4. eCollection 2012. Review. PubMed PMID: 24764510; PubMed Central PMCID: PMC3886257.

• Styskal J, Van Remmen H, Richardson A, Salmon AB. Oxidative stress and diabetes: what can we learn about insulin resistance from antioxidant mutant mouse models? Free Radic Biol Med. 2012 Jan 1;52(1):46-58. doi: 10.1016/j.freeradbiomed.2011.10.441. Epub 2011 Oct 20. Review. PubMed PMID: 22056908; PubMed Central PMCID: PMC3249484.

PICTURE VG 1 Veronica Galvan, Ph.D.

• Beauquis J, Vinuesa A, Pomilio C, Pavía P, Galván V, Saravia F. Neuronal and glial alterations, increased anxiety, and cognitive impairment before hippocampal amyloid deposition in PDAPP mice, model of Alzheimer’s disease. Hippocampus. 2014 Mar;24(3):257-69. doi: 10.1002/hipo.22219. Epub 2013 Nov 12. PubMed PMID: 24132937.

• Sun YX, Ji X, Mao X, Xie L, Jia J, Galvan V, Greenberg DA, Jin K. Differential activation of mTOR complex 1 signaling in human brain with mild to severe Alzheimer’s disease. J Alzheimers Dis. 2014;38(2):437-44. doi: 10.3233/JAD-131124. PubMed PMID: 23979023.

• Lin AL, Pulliam DA, Deepa SS, Halloran JJ, Hussong SA, Burbank RR, Bresnen A, Liu Y, Podlutskaya N, Soundararajan A, Muir E, Duong TQ, Bokov AF, Viscomi C, Zeviani M, Richardson AG, Van Remmen H, Fox PT, Galvan V. Decreased in vitro mitochondrial function is associated with enhanced brain metabolism, blood flow, and memory in Surf1-deficient mice. J Cereb Blood Flow Metab. 2013 Oct;33(10):1605-11. doi: 10.1038/jcbfm.2013.116. Epub 2013 Jul 10. PubMed PMID: 23838831; PubMed Central PMCID: PMC3790931.

• Lin AL, Zheng W, Halloran JJ, Burbank RR, Hussong SA, Hart MJ, Javors M, Shih YY, Muir E, Solano Fonseca R, Strong R, Richardson AG, Lechleiter JD, Fox PT, Galvan V. Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer’s disease. J Cereb Blood Flow Metab. 2013 Sep;33(9):1412-21. doi: 10.1038/jcbfm.2013.82. Epub 2013 Jun 26. PubMed PMID: 23801246; PubMed Central PMCID: PMC3764385.

• Pierce A, Podlutskaya N, Halloran JJ, Hussong SA, Lin PY, Burbank R, Hart MJ, Galvan V. Over-expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by rapamycin and is sufficient to ameliorate Alzheimer’s-like deficits in mice modeling the disease. J Neurochem. 2013 Mar;124(6):880-93. doi: 10.1111/jnc.12080. Epub 2012 Dec 26. PubMed PMID: 23121022.

• Beauquis J, Pavía P, Pomilio C, Vinuesa A, Podlutskaya N, Galvan V, Saravia F. Environmental enrichment prevents astroglial pathological changes in the hippocampus of APP transgenic mice, model of Alzheimer’s disease. Exp Neurol. 2013 Jan;239:28-37. doi: 10.1016/j.expneurol.2012.09.009. Epub 2012 Sep 28.PubMed PMID: 23022919.

• Halloran J, Hussong SA, Burbank R, Podlutskaya N, Fischer KE, Sloane LB, Austad SN, Strong R, Richardson A, Hart MJ, Galvan V. Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice. Neuroscience. 2012 Oct 25;223:102-13. doi: 10.1016/j.neuroscience.2012.06.054. Epub 2012 Jun 28. PubMed PMID: 22750207; PubMed Central PMCID: PMC3454865.

• Hart MJ, Glicksman M, Liu M, Sharma MK, Cuny G, Galvan V. Development of a high-throughput screen targeting caspase-8-mediated cleavage of the amyloid precursor protein. Anal Biochem. 2012 Feb 15;421(2):467-76. doi: 10.1016/j.ab.2011.11.020. Epub 2011 Dec 1. PubMed PMID: 22178911.