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Healthspan and Functional Assessment Core Publications

13 Feb 2015

A listing of publications from the San Antonio Nathan Shock Center Healthspan and Functional Assessment Core.

2015


Zhang Y, Fischer KE, Soto V, Liu Y, Sosnowska D, Richardson A, Salmon AB. Obesity-induced oxidative stress, accelerated functional decline with age and increased mortality in mice. Arch Biochem Biophys. 2015 Jan 3. pii: S0003-9861(14)00443-3. doi: 10.1016/j.abb.2014.12.018. [Epub ahead of print] PubMed PMID: 25558793.

2014


Halter JB, Musi N, McFarland Horne F, Crandall JP, Goldberg A, Harkless L, Hazzard WR, Huang ES, Kirkman MS, Plutzky J, Schmader KE, Zieman S, High KP. Diabetes and cardiovascular disease in older adults: current status and future directions. Diabetes. 2014 Aug;63(8):2578-89. doi: 10.2337/db14-0020. PubMed PMID: 25060886; PubMed Central PMCID: PMC4113072.

Tardif S, Ross C, Bergman P, Fernandez E, Javors M, Salmon A, Spross J, Strong R, Richardson A. Testing Efficacy of Administration of the Antiaging Drug Rapamycin in a Nonhuman Primate, the Common Marmoset. J Gerontol A Biol Sci Med Sci. 2014. doi: 10.1093/gerona/glu101. PubMed PMID: 25038772.

Beauquis J, Vinuesa A, Pomilio C, Pavia P, Galvan V, Saravia F. Neuronal and glial alterations, increased anxiety, and cognitive impairment before hippocampal amyloid deposition in PDAPP mice, model of Alzheimer’s disease. Hippocampus. 2014;24(3):257-69. doi: 10.1002/hipo.22219. PubMed PMID: 24132937.

Grimes KM, Reddy AK, Lindsey ML, Buffenstein R. And the beat goes on: maintained cardiovascular function during aging in the longest-lived rodent, the naked mole-rat. Am J Physiol Heart Circ Physiol. 2014 Aug 1;307(3):H284-91. doi: 10.1152/ajpheart.00305.2014. Epub 2014 Jun 6. PubMed PMID: 24906918; PubMed Central PMCID: PMC4121653.

Ghosh S, Lertwattanarak R, Garduño JD, Galeana JJ, Li J, Zamarripa F, Lancaster JL, Mohan S, Hussey S, Musi N. Elevated Muscle TLR4 Expression and Metabolic Endotoxemia in Human Aging. J Gerontol A Biol Sci Med Sci. 2014 May 20. pii: glu067. [Epub ahead of print] PubMed PMID: 24846769.

Miller RA, Harrison DE, Astle CM, Fernandez E, Flurkey K, Han M, Javors MA, Li X, Nadon NL, Nelson JF, Pletcher S, Salmon AB, Sharp ZD, Van Roekel S, Winkleman L, Strong R. Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction. Aging Cell. 2014;13(3):468-77. doi: 10.1111/acel.12194. PubMed PMID: 24341993 PMCID: PMC4032600.

Burch JB, Augustine AD, Frieden LA, Hadley E, Howcroft TK, Johnson R, Khalsa PS, Kohanski RA, Li XL, Macchiarini F, Niederehe G, Oh YS, Pawlyk AC, Rodriguez H, Rowland JH, Shen GL, Sierra F, Wise BC. Advances in geroscience: impact on healthspan and chronic disease. J Gerontol A Biol Sci Med Sci. 2014;69 Suppl 1:S1-3. doi: 10.1093/gerona/glu041. PubMed PMID: 24833579 PMCID: PMC4036419.

Zhang Y, Bokov A, Gelfond J, Soto V, Ikeno Y, Hubbard G, Diaz V, Sloane L, Maslin K, Treaster S, Rendon S, van Remmen H, Ward W, Javors M, Richardson A, Austad SN, Fischer K. Rapamycin extends life and health in C57BL/6 mice. J Gerontol A Biol Sci Med Sci. 2014;69(2):119-30. doi: 10.1093/gerona/glt056. PubMed PMID: 23682161 PMCID: PMC4038246.

Ryu J, Galan AK, Xin X, Dong F, Abdul-Ghani MA, Zhou L, Wang C, Li C, Holmes BM, Sloane LB, Austad SN, Guo S, Musi N, DeFronzo RA, Deng C, White MF, Liu F, Dong LQ. APPL1 potentiates insulin sensitivity by facilitating the binding of IRS1/2 to the insulin receptor. Cell reports. 2014;7(4):1227-38. doi: 10.1016/j.celrep.2014.04.006. PubMed PMID: 24813896.

Fontana L, Kennedy BK, Longo VD, Seals D, Melov S. Medical research: treat ageing. Nature. 2014;511(7510):405-7. doi: 10.1038/511405a. PubMed PMID: 25056047.

Yabluchanskiy A, Ma Y, Chiao YA, Lopez EF, Voorhees AP, Toba H, Hall ME, Han HC, Lindsey ML, Jin YF. Cardiac aging is initiated by matrix metalloproteinase-9-mediated endothelial dysfunction. American journal of physiology Heart and circulatory physiology. 2014;306(10):H1398-407. doi: 10.1152/ajpheart.00090.2014. PubMed PMID: 24658018 PMCID: PMC4024719.

Tripathy D, Clement SC, Schwenke DC, Banerji M, Bray GA, Buchanan TA, Gastaldelli A, Henry RR, Kitabchi AE, Mudaliar S, Ratner RE, Stentz FB, Musi N, Reaven PD, DeFronzo RA. Baseline adiponectin levels do not influence the response to pioglitazone in ACT NOW. Diabetes Care. 2014 Jun;37(6):1706-11. doi: 10.2337/dc13-1745. Epub 2014 Apr 4. PubMed PMID: 24705615.

Liu M, Bai J, He S, Villarreal R, Hu D, Zhang C, Yang X, Liang H, Slaga TJ, Yu Y, Zhou Z, Blenis J, Scherer PE, Dong LQ, Liu F. Grb10 promotes lipolysis and thermogenesis by phosphorylation-dependent feedback inhibition of mTORC1. Cell metabolism. 2014;19(6):967-80. doi: 10.1016/j.cmet.2014.03.018. PubMed PMID: 24746805 PMCID: PMC4064112.

Hasty P, Livi CB, Dodds SG, Jones D, Strong R, Javors M, Fischer KE, Sloane L, Murthy K, Hubbard G, Sun L, Hurez V, Curiel TJ, Sharp ZD. eRapa restores a normal life span in a FAP mouse model. Cancer prevention research. 2014;7(1):169-78. doi: 10.1158/1940-6207.CAPR-13-0299. PubMed PMID: 24282255 PMCID: PMC4058993.

Pan H, Qin K, Guo Z, Ma Y, April C, Gao X, Andrews TG, Bokov A, Zhang J, Chen Y, Weintraub ST, Fan JB, Wang D, Hu Y, Aune GJ, Lindsey ML, Li R. Negative elongation factor controls energy homeostasis in cardiomyocytes. Cell reports. 2014;7(1):79-85. doi: 10.1016/j.celrep.2014.02.028. PubMed PMID: 24656816.

Shivshankar P, Halade GV, Calhoun C, Escobar GP, Mehr AJ, Jimenez F, Martinez C, Bhatnagar H, Mjaatvedt CH, Lindsey ML, Le Saux CJ. Caveolin-1 deletion exacerbates cardiac interstitial fibrosis by promoting M2 macrophage activation in mice after myocardial infarction. Journal of molecular and cellular cardiology. 2014;76C:84-93. doi: 10.1016/j.yjmcc.2014.07.020. PubMed PMID: 25128086.

Hussey SE, Lum H, Alvarez A, Cipriani Y, Garduño-Garcia J, Anaya L, Dube J, Musi N. A sustained increase in plasma NEFA upregulates the Toll-like receptor network in human muscle. Diabetologia. 2014 Mar;57(3):582-91. doi: 10.1007/s00125-013-3111-x. Epub 2013 Dec 14. PubMed PMID: 24337154; PubMed Central PMCID: PMC3945433.

Grimes KM, Voorhees A, Chiao YA, Han HC, Lindsey ML, Buffenstein R. Cardiac function of the naked mole-rat: ecophysiological responses to working underground. American journal of physiology Heart and circulatory physiology. 2014;306(5):H730-7. doi: 10.1152/ajpheart.00831.2013. PubMed PMID: 24363308 PMCID: PMC3949069.

2013


Defronzo RA, Tripathy D, Schwenke DC, Banerji M, Bray GA, Buchanan TA, Clement SC, Henry RR, Kitabchi AE, Mudaliar S, Ratner RE, Stentz FB, Musi N, Reaven PD, Gastaldelli A; ACT NOW Study. Prediction of diabetes based on baseline metabolic  characteristics in individuals at high risk. Diabetes Care. 2013 Nov;36(11):3607-12. doi: 10.2337/dc13-0520. Epub 2013 Sep 23. PubMed PMID: 24062330; PubMed Central PMCID: PMC3816921.

Deleon-Pennell KY, de Castro Bras LE, Lindsey ML. Circulating Porphyromonas gingivalis lipopolysaccharide resets cardiac homeostasis in mice through a matrix metalloproteinase-9-dependent mechanism. Physiological reports. 2013;1(5):e00079. doi: 10.1002/phy2.79. PubMed PMID: 24159380 PMCID: PMC3804276.

Livi CB, Hardman RL, Christy BA, Dodds SG, Jones D, Williams C, Strong R, Bokov A, Javors MA, Ikeno Y, Hubbard G, Hasty P, Sharp ZD. Rapamycin extends life span of Rb1+/- mice by inhibiting neuroendocrine tumors. Aging. 2013;5(2):100-10. PubMed PMID: 23454836 PMCID: PMC3616197.

Muscogiuri G, Salmon AB, Aguayo-Mazzucato C, Li M, Balas B, Guardado-Mendoza R, Giaccari A, Reddick RL, Reyna SM, Weir G, Defronzo RA, Van Remmen H, Musi N. Genetic disruption of SOD1 gene causes glucose intolerance and impairs β-cell function. Diabetes. 2013 Dec;62(12):4201-7. doi: 10.2337/db13-0314. Epub 2013 Sep 5. PubMed PMID: 24009256; PubMed Central PMCID: PMC3837066.

Defronzo RA, Tripathy D, Schwenke DC, Banerji M, Bray GA, Buchanan TA, Clement SC, Gastaldelli A, Henry RR, Kitabchi AE, Mudaliar S, Ratner RE, Stentz FB, Musi N, Reaven PD; ACT NOW Study. Prevention of diabetes with pioglitazone in ACT NOW: physiologic correlates. Diabetes. 2013 Nov;62(11):3920-6. doi: 10.2337/db13-0265. Epub 2013 Jul 17. PubMed PMID: 23863810; PubMed Central PMCID: PMC3806596.

Halade GV, Ma Y, Ramirez TA, Zhang J, Dai Q, Hensler JG, Lopez EF, Ghasemi O, Jin YF, Lindsey ML. Reduced BDNF attenuates inflammation and angiogenesis to improve survival and cardiac function following myocardial infarction in mice. American journal of physiology Heart and circulatory physiology. 2013;305(12):H1830-42. doi: 10.1152/ajpheart.00224.2013. PubMed PMID: 24142413 PMCID: PMC3882541.

Lin AL, Pulliam DA, Deepa SS, Halloran JJ, Hussong SA, Burbank RR, Bresnen A, Liu Y, Podlutskaya N, Soundararajan A, Muir E, Duong TQ, Bokov AF, Viscomi C, Zeviani M, Richardson AG, Van Remmen H, Fox PT, Galvan V. Decreased in vitro mitochondrial function is associated with enhanced brain metabolism, blood flow, and memory in Surf1-deficient mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2013;33(10):1605-11. doi: 10.1038/jcbfm.2013.116. PubMed PMID: 23838831 PMCID: PMC3790931.

Liang H, Hussey SE, Sanchez-Avila A, Tantiwong P, Musi N. Effect of lipopolysaccharide on inflammation and insulin action in human muscle. PLoS One.  2013 May 21;8(5):e63983. doi: 10.1371/journal.pone.0063983. Print 2013. PubMed PMID: 23704966; PubMed Central PMCID: PMC3660322.

Pierce A, Podlutskaya N, Halloran JJ, Hussong SA, Lin PY, Burbank R, Hart MJ, Galvan V. Over-expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by rapamycin and is sufficient to ameliorate Alzheimer’s-like deficits in mice modeling the disease. Journal of neurochemistry. 2013;124(6):880-93. doi: 10.1111/jnc.12080. PubMed PMID: 23121022.

Reyna SM, Tantiwong P, Cersosimo E, Defronzo RA, Sriwijitkamol A, Musi N. Short-term exercise training improves insulin sensitivity but does not inhibit inflammatory pathways in immune cells from insulin-resistant subjects. J Diabetes Res. 2013;2013:107805. doi: 10.1155/2013/107805. Epub 2013 Mar 13. PubMed PMID: 23671849; PubMed Central PMCID: PMC3647562.

Heaberlin JR, Ma Y, Zhang J, Ahuja SS, Lindsey ML, Halade GV. Obese and diabetic KKAy mice show increased mortality but improved cardiac function following myocardial infarction. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. 2013;22(6):481-7. doi: 10.1016/j.carpath.2013.06.002. PubMed PMID: 23896047 PMCID: PMC3965668.

Fok WC, Zhang Y, Salmon AB, Bhattacharya A, Gunda R, Jones D, Ward W, Fisher K, Richardson A, Perez VI. Short-term treatment with rapamycin and dietary restriction have overlapping and distinctive effects in young mice. J Gerontol A Biol Sci Med Sci. 2013;68(2):108-16. doi: 10.1093/gerona/gls127. PubMed PMID: 22570137 PMCID: PMC3598360.

Liang H, Tantiwong P, Sriwijitkamol A, Shanmugasundaram K, Mohan S, Espinoza S, Defronzo RA, Dubé JJ, Musi N. Effect of a sustained reduction in plasma free fatty acid concentration on insulin signalling and inflammation in skeletal muscle from human subjects. J Physiol. 2013 Jun 1;591(Pt 11):2897-909. doi: 10.1113/jphysiol.2012.247510. Epub 2013 Mar 25. PubMed PMID: 23529132; PubMed Central PMCID: PMC3690693.

Ma Y, Halade GV, Zhang J, Ramirez TA, Levin D, Voorhees A, Jin YF, Han HC, Manicone AM, Lindsey ML. Matrix metalloproteinase-28 deletion exacerbates cardiac dysfunction and rupture after myocardial infarction in mice by inhibiting M2 macrophage activation. Circulation research. 2013;112(4):675-88. doi: 10.1161/CIRCRESAHA.111.300502. PubMed PMID: 23261783 PMCID: PMC3597388.

Deepa SS, Pulliam D, Hill S, Shi Y, Walsh ME, Salmon A, Sloane L, Zhang N, Zeviani M, Viscomi C, Musi N, Van Remmen H. Improved insulin sensitivity associated with reduced mitochondrial complex IV assembly and activity. FASEB J. 2013 Apr;27(4):1371-80. doi: 10.1096/fj.12-221879. Epub 2012 Dec 14. PubMed PMID: 23241310.

Lin AL, Zheng W, Halloran JJ, Burbank RR, Hussong SA, Hart MJ, Javors M, Shih YY, Muir E, Solano Fonseca R, Strong R, Richardson AG, Lechleiter JD, Fox PT, Galvan V. Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer’s disease. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2013;33(9):1412-21. doi: 10.1038/jcbfm.2013.82. PubMed PMID: 23801246 PMCID: PMC3764385

Bai X, Fermandez E, Gould G, Strong R. Homozygous Deletion of Glutathione Peroxidase 1 and Aldehyde Dehydrogenase 1a1 Genes Is Not Associated with Schizophrenia-Like Behavior in Mice. Journal of biochemical and pharmacological research. 2013;1(4):228-35. PubMed PMID: 24494173 PMCID: PMC3909525.

Styskal J, Nwagwu FA, Watkins YN, Liang H, Richardson A, Musi N, Salmon AB. Methionine sulfoxide reductase A affects insulin resistance by protecting insulin receptor function. Free Radic Biol Med. 2013 Mar;56:123-32. doi: 10.1016/j.freeradbiomed.2012.10.544. Epub 2012 Oct 23. PubMed PMID: 23089224; PubMed Central PMCID: PMC3578155.

Beauquis J, Pavia P, Pomilio C, Vinuesa A, Podlutskaya N, Galvan V, Saravia F. Environmental enrichment prevents astroglial pathological changes in the hippocampus of APP transgenic mice, model of Alzheimer’s disease. Experimental neurology. 2013;239:28-37. doi: 10.1016/j.expneurol.2012.09.009. PubMed PMID: 23022919.

2012


Tabatabai-Mir H, Sataranatarajan K, Lee HJ, Bokov AF, Fernandez E, Diaz V, Choudhury GG, Richardson A, Kasinath BS. Rapamycin selectively alters serum chemistry in diabetic mice. Pathobiology of aging & age related diseases. 2012;2. doi: 10.3402/pba.v2i0.15896. PubMed PMID: 22953036 PMCID: PMC3417581.

Ma Y, Zhang X, Bao H, Mi S, Cai W, Yan H, Wang Q, Wang Z, Yan J, Fan GC, Lindsey ML, Hu Z. Toll-like receptor (TLR) 2 and TLR4 differentially regulate doxorubicin induced cardiomyopathy in mice. PLoS One. 2012;7(7):e40763. doi: 10.1371/journal.pone.0040763. PubMed PMID: 22808256 PMCID: PMC3396603.

Hussey SE, Liang H, Costford SR, Klip A, DeFronzo RA, Sanchez-Avila A, Ely B, Musi N. TAK-242, a small-molecule inhibitor of Toll-like receptor 4 signalling, unveils similarities and differences in lipopolysaccharide- and lipid-induced inflammation and insulin resistance in muscle cells. Biosci Rep. 2012 Nov 30;33(1):37-47. doi: 10.1042/BSR20120098. PubMed PMID: 23050932; PubMed Central PMCID: PMC3522475.

Ramirez TA, Jourdan-Le Saux C, Joy A, Zhang J, Dai Q, Mifflin S, Lindsey ML. Chronic and intermittent hypoxia differentially regulate left ventricular inflammatory and extracellular matrix responses. Hypertension research : official journal of the Japanese Society of Hypertension. 2012;35(8):811-8. doi: 10.1038/hr.2012.32. PubMed PMID: 22495609 PMCID: PMC3419973.

Sataranatarajan K, Feliers D, Mariappan MM, Lee HJ, Lee MJ, Day RT, Yalamanchili HB, Choudhury GG, Barnes JL, Van Remmen H, Richardson A, Kasinath BS. Molecular events in matrix protein metabolism in the aging kidney. Aging Cell. 2012;11(6):1065-73. doi: 10.1111/acel.12008. PubMed PMID: 23020145.

Wey MC, Fernandez E, Martinez PA, Sullivan P, Goldstein DS, Strong R. Neurodegeneration and motor dysfunction in mice lacking cytosolic and mitochondrial aldehyde dehydrogenases: implications for Parkinson’s disease. PLoS One. 2012;7(2):e31522. doi: 10.1371/journal.pone.0031522. PubMed PMID: 22384032 PMCID: PMC3284575.

Liu M, Xiang R, Wilk SA, Zhang N, Sloane LB, Azarnoush K, Zhou L, Chen H, Xiang G, Walter CA, Austad SN, Musi N, DeFronzo RA, Asmis R, Scherer PE, Dong LQ, Liu F. Fat-specific DsbA-L overexpression promotes adiponectin multimerization and protects mice from diet-induced obesity and insulin resistance. Diabetes. 2012;61(11):2776-86. doi: 10.2337/db12-0169. PubMed PMID: 22807031 PMCID: PMC3478538.

Hinojosa CA, Mgbemena V, Van Roekel S, Austad SN, Miller RA, Bose S, Orihuela CJ. Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence. Experimental gerontology. 2012;47(12):958-65. doi: 10.1016/j.exger.2012.08.013. PubMed PMID: 22981852 PMCID: PMC3490008.

Yoshioka J, Chutkow WA, Lee S, Kim JB, Yan J, Tian R, Lindsey ML, Feener EP, Seidman CE, Seidman JG, Lee RT. Deletion of thioredoxin-interacting protein in mice impairs mitochondrial function but protects the myocardium from ischemia-reperfusion injury. The Journal of clinical investigation. 2012;122(1):267-79. doi: 10.1172/JCI44927. PubMed PMID: 22201682 PMCID: PMC3248280.

Li M, Verdijk LB, Sakamoto K, Ely B, van Loon LJ, Musi N. Reduced AMPK-ACC and mTOR signaling in muscle from older men, and effect of resistance exercise. Mech Ageing Dev. 2012 Nov-Dec;133(11-12):655-64. doi: 10.1016/j.mad.2012.09.001. Epub 2012 Sep 19. PubMed PMID: 23000302; PubMed Central PMCID: PMC3631591.

Shi Y, Pulliam DA, Liu Y, Hamilton RT, Jernigan AL, Bhattacharya A, Sloane LB, Qi W, Chaudhuri A, Buffenstein R, Ungvari Z, Austad SN, Van Remmen H. Reduced mitochondrial ROS, enhanced antioxidant defense, and distinct age-related changes in oxidative damage in muscles of long-lived Peromyscus leucopus. American journal of physiology Regulatory, integrative and comparative physiology. 2013;304(5):R343-55. doi: 10.1152/ajpregu.00139.2012. PubMed PMID: 23325454 PMCID: PMC4116415.

Grimes KM, Lindsey ML, Gelfond JA, Buffenstein R. Getting to the heart of the matter: age-related changes in diastolic heart function in the longest-lived rodent, the naked mole rat. J Gerontol A Biol Sci Med Sci. 2012;67(4):384-94. doi: 10.1093/gerona/glr222. PubMed PMID: 22367435 PMCID: PMC3309875.

Chiao YA, Ramirez TA, Zamilpa R, Okoronkwo SM, Dai Q, Zhang J, Jin YF, Lindsey ML. Matrix metalloproteinase-9 deletion attenuates myocardial fibrosis and diastolic dysfunction in ageing mice. Cardiovascular research. 2012;96(3):444-55. doi: 10.1093/cvr/cvs275. PubMed PMID: 22918978 PMCID: PMC3500048.

Halloran J, Hussong SA, Burbank R, Podlutskaya N, Fischer KE, Sloane LB, Austad SN, Strong R, Richardson A, Hart MJ, Galvan V. Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice. Neuroscience. 2012;223C:102-13. Epub 2012/07/04. doi: S0306-4522(12)00672-0 [pii]
10.1016/j.neuroscience.2012.06.054. PubMed PMID: 22750207.

Wilkinson JE, Burmeister L, Brooks SV, Chan CC, Friedline S, Harrison DE, Hejtmancik JF, Nadon N, Strong R, Wood LK, Woodward MA, Miller RA. Rapamycin slows aging in mice. Aging Cell. 2012. Epub 2012/05/17. doi: 10.1111/j.1474-9726.2012.00832.x. PubMed PMID: 22587563.

Nelson JF, Strong R, Bokov A, Diaz V, Ward W. Probing the relationship between insulin sensitivity and longevity using genetically modified mice. J Gerontol A Biol Sci Med Sci. 2012;67(12):1332-8. doi: 10.1093/gerona/gls199. PubMed PMID: 23089336 PMCID: PMC3670160.

2011


Liao CY, Rikke BA, Johnson TE, Gelfond JA, Diaz V, Nelson JF. Fat maintenance is a predictor of the murine lifespan response to dietary restriction. Aging Cell. 2011;10(4):629-39. doi: 10.1111/j.1474-9726.2011.00702.x. PubMed PMID: 21388497 PMCID: PMC3685291.

Bokov AF, Garg N, Ikeno Y, Thakur S, Musi N, DeFronzo RA, Zhang N, Erickson RC, Gelfond J, Hubbard GB, Adamo ML, Richardson A. Does reduced IGF-1R signaling in Igf1r+/- mice alter aging? PLoS One. 2011;6(11):e26891. doi: 10.1371/journal.pone.0026891. Epub 2011 Nov 23. PubMed PMID: 22132081; PubMed Central PMCID: PMC3223158.

Miyasato SK, Loeffler J, Shohet R, Zhang J, Lindsey M, Le Saux CJ. Caveolin-1 modulates TGF-beta1 signaling in cardiac remodeling. Matrix biology : journal of the International Society for Matrix Biology. 2011;30(5-6):318-29. doi: 10.1016/j.matbio.2011.05.003. PubMed PMID: 21641995.

Halade GV, Williams PJ, Lindsey ML, Fernandes G. Fish oil decreases inflammation and reduces cardiac remodeling in rosiglitazone treated aging mice. Pharmacological research : the official journal of the Italian Pharmacological Society. 2011;63(4):300-7. doi: 10.1016/j.phrs.2010.12.012. PubMed PMID: 21193042 PMCID: PMC3326603.

Ghosh S, Lertwattanarak R, Lefort N, Molina-Carrion M, Joya-Galeana J, Bowen BP, Garduno-Garcia Jde J, Abdul-Ghani M, Richardson A, DeFronzo RA, Mandarino L, Van Remmen H, Musi N. Reduction in reactive oxygen species production by mitochondria from elderly subjects with normal and impaired glucose tolerance.
Diabetes. 2011 Aug;60(8):2051-60. doi: 10.2337/db11-0121. Epub 2011 Jun 15. PubMed PMID: 21677280; PubMed Central PMCID: PMC3142073.

McCurdy SM, Dai Q, Zhang J, Zamilpa R, Ramirez TA, Dayah T, Nguyen N, Jin YF, Bradshaw AD, Lindsey ML. SPARC mediates early extracellular matrix remodeling following myocardial infarction. American journal of physiology Heart and circulatory physiology. 2011;301(2):H497-505. doi: 10.1152/ajpheart.01070.2010. PubMed PMID: 21602472 PMCID: PMC3154667.

Zamilpa R, Kanakia R, Cigarroa Jt, Dai Q, Escobar GP, Martinez H, Jimenez F, Ahuja SS, Lindsey ML. CC chemokine receptor 5 deletion impairs macrophage activation and induces adverse remodeling following myocardial infarction. American journal of physiology Heart and circulatory physiology. 2011;300(4):H1418-26. doi: 10.1152/ajpheart.01002.2010. PubMed PMID: 21297029 PMCID: PMC3075032.

Miller RA, Harrison DE, Astle CM, Baur JA, Boyd AR, de Cabo R, Fernandez E, Flurkey K, Javors MA, Nelson JF, Orihuela CJ, Pletcher S, Sharp ZD, Sinclair D, Starnes JW, Wilkinson JE, Nadon NL, Strong R. Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci. 2011;66(2):191-201. Epub 2010/10/27. doi: glq178 [pii]
10.1093/gerona/glq178. PubMed PMID: 20974732.

2010


Spilman P, Podlutskaya N, Hart MJ, Debnath J, Gorostiza O, Bredesen D, Richardson A, Strong R, Galvan V. Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer’s disease. PLoS One. 2010;5(4):e9979. Epub 2010/04/09. doi: 10.1371/journal.pone.0009979. PubMed PMID: 20376313.

2009


Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, Carter CS, Pahor M, Javors MA, Fernandez E, Miller RA. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature. 2009;460(7253):392-5. Epub 2009/07/10. doi: nature08221 [pii]
10.1038/nature08221. PubMed PMID: 19587680.

Huber WR, Sierra F. The longevity dividend: why invest in basic aging reserach? Canadian journal on aging = La revue canadienne du vieillissement. 2009;28(4):391-4; French 5-8. PubMed PMID: 20166274.