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Publications from the 2012-2013 Emerging Technologies Awardees

25 Nov 2014

The San Antonio Nathan Shock Center Research Development Core would like to highlight the publications from the 2012-2013 Awardees of the Emerging Technologies Award.

 

EllenKraig Ellen Kraig, Ph.D.

• Rubicz R, Yolken R, Drigalenko E, Carless MA, Dyer TD, Bauman L, Melton PE, Kent JW Jr, Harley JB, Curran JE, Johnson MP, Cole SA, Almasy L, Moses EK, Dhurandhar NV, Kraig E, Blangero J, Leach CT, Göring HH. A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1). PLoS Genet. 2013; 9(1):e1003147. doi: 10.1371/journal.pgen.1003147. Epub 2013 Jan 10. PubMed PMID: 23326239; PubMed Central PMCID: PMC3542101.

• Majumder S, Caccamo A, Medina DX, Benavides AD, Javors MA, Kraig E, Strong R, Richardson A, Oddo S. Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling. Aging Cell. 2012 Apr; 11(2):326-35. doi: 10.1111/j.1474-9726.2011.00791.x. Epub 2012 Feb 1. PubMed PMID: 22212527; PubMed Central PMCID: PMC3306461.

• Rubicz R, Leach CT, Kraig E, Dhurandhar NV, Grubbs B, Blangero J, Yolken R, Göring HH. Seroprevalence of 13 common pathogens in a rapidly growing U.S. minority population: Mexican Americans from San Antonio, TX. BMC Res Notes. 2011 Oct 21; 4:433. doi: 10.1186/1756-0500-4-433. PubMed PMID: 22018212; PubMed Central PMCID: PMC3214184.

• Rubicz R, Leach CT, Kraig E, Dhurandhar NV, Duggirala R, Blangero J, Yolken R, Göring HH. Genetic factors influence serological measures of common infections. Hum Hered. 2011; 72(2):133-41. doi: 10.1159/000331220. Epub 2011 Oct 11. PubMed PMID: 21996708; PubMed Central PMCID: PMC3214928.

• Stacy S, Williams EL, Standifer NE, Pasquali A, Krolick KA, Infante AJ, Kraig E. Maintenance of immune tolerance to a neo-self acetylcholine receptor antigen with aging: implications for late-onset autoimmunity. J Immunol. 2010 Jun 1; 184(11):6067-75. doi: 10.4049/jimmunol.0901618. Epub 2010 Apr 30. PubMed PMID: 20435934; PubMed Central PMCID: PMC2895814.

 

CurielTyler Tyler Curiel, M.D., MPH

• Mahalingam D, Mita M, Sarantopoulos J, Wood L, Amaravadi RK, Davis LE, Mita AC, Curiel TJ, Espitia CM, Nawrocki ST, Giles FJ, Carew JS. Combined autophagy and HDAC inhibition: a phase I safety, tolerability, pharmacokinetic, and pharmacodynamic analysis of hydroxychloroquine in combination with the HDAC inhibitor vorinostat in patients with advanced solid tumors. Autophagy. 2014 Aug; 10(8):1403-14. doi: 10.4161/auto.29231. Epub 2014 May 20. PubMed PMID: 24991835.

• Yuan B, Cheng L, Chiang HC, Xu X, Han Y, Su H, Wang L, Zhang B, Lin J, Li X, Xie X, Wang T, Tekmal RR, Curiel TJ, Yuan ZM, Elledge R, Hu Y, Ye Q, Li R. A phosphotyrosine switch determines the antitumor activity of ERβ. J Clin Invest. 2014 Aug 1;124(8):3378-90. doi: 10.1172/JCI74085. Epub 2014 Jun 24. PubMed PMID: 24960160; PubMed Central PMCID: PMC4109526.

• Messer JC, Shariat SF, Dinney CP, Novara G, Fradet Y, Kassouf W, Karakiewicz PI, Fritsche HM, Izawa JI, Lotan Y, Skinner EC, Tilki D, Ficarra V, Volkmer BG, Isbarn H, Wei C, Lerner SP, Curiel TJ, Kamat AM, Svatek RS. Female gender is associated with a worse survival after radical cystectomy for urothelial carcinoma of the bladder: a competing risk analysis. Urology. 2014 Apr; 83(4):863-7. doi: 10.1016/j.urology.2013.10.060. Epub 2014 Jan 31. PubMed PMID: 24485993.

• Hasty P, Livi CB, Dodds SG, Jones D, Strong R, Javors M, Fischer KE, Sloane L, Murthy K, Hubbard G, Sun L, Hurez V, Curiel TJ, Sharp ZD. eRapa restores a normal life span in a FAP mouse model. Cancer Prev Res (Phila). 2014 Jan; 7(1):169-78. doi: 10.1158/1940-6207.CAPR-13-0299. Epub 2013 Nov 26. PubMed PMID: 24282255; PubMed Central PMCID: PMC4058993.

• Brumlik MJ, Pandeswara S, Ludwig SM, Jeansonne DP, Lacey MR, Murthy K, Daniel BJ, Wang RF, Thibodeaux SR, Church KM, Hurez V, Kious MJ, Zhang B, Alagbala A, Xia X, Curiel TJ. TgMAPK1 is a Toxoplasma gondii MAP kinase that hijacks host MKK3 signals to regulate virulence and interferon-γ-mediated nitric oxide production. Exp Parasitol. 2013 Jul; 134(3):389-99. doi: 10.1016/j.exppara.2013.03.016. Epub 2013 Mar 27. PubMed PMID: 23541881.

• Wang L, Fan J, Chen S, Zhang Y, Curiel TJ, Zhang B. Graft-versus-host disease is enhanced by selective CD73 blockade in mice. PLoS One. 2013;8(3):e58397. doi: 10.1371/journal.pone.0058397. Epub 2013 Mar 8. PubMed PMID: 23520507; PubMed Central PMCID: PMC3592842.

• Sharp ZD, Curiel TJ, Livi CB. Chronic mechanistic target of rapamycin inhibition: preventing cancer to delay aging, or vice versa?. Interdiscip Top Gerontol. 2013; 38:1-16. doi: 10.1159/000343625. Epub 2013 Jan 17. Review. PubMed PMID: 23503511.

• Tomihara K, Curiel TJ, Zhang B. Optimization of immunotherapy in elderly cancer patients. Crit Rev Oncog. 2013; 18(6):573-83. Review. PubMed PMID: 24579736; PubMed Central PMCID: PMC3960499.

• Hasty P, Sharp ZD, Curiel TJ, Campisi J. mTORC1 and p53: clash of the gods? Cell Cycle. 2013 Jan 1; 12(1):20-5. PubMed PMID: 23255104; PubMed Central PMCID: PMC3570511.

• Sun L, Hurez VJ, Thibodeaux SR, Kious MJ, Liu A, Lin P, Murthy K, Pandeswara S, Shin T, Curiel TJ. Aged regulatory T cells protect from autoimmune inflammation despite reduced STAT3 activation and decreased constraint of IL-17 producing T cells. Aging Cell. 2012 Jun; 11(3):509-19. doi: 10.1111/j.1474-9726.2012.00812.x. Epub 2012 Mar 22. PubMed PMID: 22372596.

• Collins-Burow BM, Antoon JW, Frigo DE, Elliott S, Weldon CB, Boue SM, Beckman BS, Curiel TJ, Alam J, McLachlan JA, Burow ME. Antiestrogenic activity of flavonoid phytochemicals mediated via the c-Jun N-terminal protein kinase pathway. Cell-type specific regulation of estrogen receptor alpha. J Steroid Biochem Mol Biol. 2012 Oct; 132(1-2):186-93. doi: 10.1016/j.jsbmb.2012.05.004. Epub 2012 May 24. PubMed PMID: 22634477; PubMed Central PMCID: PMC4083692.

• Hurez V, Daniel BJ, Sun L, Liu AJ, Ludwig SM, Kious MJ, Thibodeaux SR, Pandeswara S, Murthy K, Livi CB, Wall S, Brumlik MJ, Shin T, Zhang B, Curiel TJ. Mitigating age-related immune dysfunction heightens the efficacy of tumor immunotherapy in aged mice. Cancer Res. 2012 Apr 15; 72(8):2089-99. doi: 10.1158/0008-5472.CAN-11-3019. Epub 2012 Apr 11. PubMed PMID: 22496463; PubMed Central PMCID: PMC3328641.

Curiel TJ. Immunotherapy: a useful strategy to help combat multidrug resistance. Drug Resist Updat. 2012 Feb-Apr; 15(1-2):106-13. doi: 10.1016/j.drup.2012.03.003. Epub 2012 Apr 5. Review. PubMed PMID: 22483359.

• Ménétrier-Caux C, Curiel T, Faget J, Manuel M, Caux C, Zou W. Targeting regulatory T cells. Target Oncol. 2012 Mar; 7(1):15-28. doi: 10.1007/s11523-012-0208-y. Epub 2012 Feb 12. Review. PubMed PMID: 22327882.

• Tomihara K, Shin T, Hurez VJ, Yagita H, Pardoll DM, Zhang B, Curiel TJ, Shin T. Aging-associated B7-DC+ B cells enhance anti-tumor immunity via Th1 and Th17 induction. Aging Cell. 2012 Feb; 11(1):128-38. doi: 10.1111/j.1474-9726.2011.00764.x. Epub 2011 Nov 28. PubMed PMID: 22044484; PubMed Central PMCID: PMC3683836.

• Brumlik MJ, Nkhoma S, Kious MJ, Thompson GR 3rd, Patterson TF, Siekierka JJ, Anderson TJ, Curiel TJ. Human p38 mitogen-activated protein kinase inhibitor drugs inhibit Plasmodium falciparum replication. Exp Parasitol. 2011 Jun; 128(2):170-5. doi: 10.1016/j.exppara.2011.02.016. Epub 2011 Feb 19. PubMed PMID: 21338604; PubMed Central PMCID: PMC3076546.

• Wang L, Fan J, Thompson LF, Zhang Y, Shin T, Curiel TJ, Zhang B. CD73 has distinct roles in nonhematopoietic and hematopoietic cells to promote tumor growth in mice. J Clin Invest. 2011 Jun; 121(6):2371-82. doi: 10.1172/JCI45559. Epub 2011 May 2. PubMed PMID: 21537079; PubMed Central PMCID: PMC3104756.

• Thibodeaux SR, Curiel TJ. Immune therapy for ovarian cancer: promise and pitfalls. Int Rev Immunol. 2011 Apr-Jun;30(2-3):102-19. doi: 10.3109/08830185.2011.567361. Review. PubMed PMID: 21557637.

• Chakravarty D, Roy SS, Babu CR, Dandamudi R, Curiel TJ, Vivas-Mejia P, Lopez-Berestein G, Sood AK, Vadlamudi RK. Therapeutic targeting of PELP1 prevents ovarian cancer growth and metastasis. Clin Cancer Res. 2011 Apr 15; 17(8):2250-9. doi: 10.1158/1078-0432.CCR-10-2718. Epub 2011 Mar 18. Erratum in: Clin Cancer Res. 2013 Mar 1; 19(5):1305. PubMed PMID: 21421858; PubMed Central PMCID: PMC3731129.

• Brumlik MJ, Pandeswara S, Ludwig SM, Murthy K, Curiel TJ. Parasite mitogen-activated protein kinases as drug discovery targets to treat human protozoan pathogens. J Signal Transduct. 2011; 2011:971968. doi: 10.1155/2011/971968. Epub 2011 Feb 27. PubMed PMID: 21637385; PubMed Central PMCID: PMC3100106.

• Rhodes LV, Short SP, Neel NF, Salvo VA, Zhu Y, Elliott S, Wei Y, Yu D, Sun M, Muir SE, Fonseca JP, Bratton MR, Segar C, Tilghman SL, Sobolik-Delmaire T, Horton LW, Zaja-Milatovic S, Collins-Burow BM, Wadsworth S, Beckman BS, Wood CE, Fuqua SA, Nephew KP, Dent P, Worthylake RA, Curiel TJ, Hung MC, Richmond A, Burow ME. Cytokine receptor CXCR4 mediates estrogen-independent tumorigenesis, metastasis, and resistance to endocrine therapy in human breast cancer. Cancer Res. 2011 Jan 15; 71(2):603-13. doi: 10.1158/0008-5472.CAN-10-3185. Epub 2010 Dec 1. Erratum in: Cancer Res. 2011 May 1; 71(9):3432. PubMed PMID: 21123450; PubMed Central PMCID: PMC3140407.

• Lin PY, Sun L, Thibodeaux SR, Ludwig SM, Vadlamudi RK, Hurez VJ, Bahar R, Kious MJ, Livi CB, Wall SR, Chen L, Zhang B, Shin T, Curiel TJ. B7-H1-dependent sex-related differences in tumor immunity and immunotherapy responses. J Immunol. 2010 Sep 1;185(5):2747-53. doi: 10.4049/jimmunol.1000496. Epub 2010 Aug 4. PubMed PMID: 20686128; PubMed Central PMCID: PMC3244840.

• Tomihara K, Guo M, Shin T, Sun X, Ludwig SM, Brumlik MJ, Zhang B, Curiel TJ, Shin T. Antigen-specific immunity and cross-priming by epithelial ovarian carcinoma-induced CD11b(+)Gr-1(+) cells. J Immunol. 2010 Jun 1; 184(11):6151-60. doi: 10.4049/jimmunol.0903519. Epub 2010 Apr 28. PubMed PMID: 20427766.

• Jin D, Fan J, Wang L, Thompson LF, Liu A, Daniel BJ, Shin T, Curiel TJ, Zhang B. CD73 on tumor cells impairs antitumor T-cell responses: a novel mechanism of tumor-induced immune suppression. Cancer Res. 2010 Mar 15; 70(6):2245-55. doi: 10.1158/0008-5472.CAN-09-3109. Epub 2010 Feb 23. PubMed PMID: 20179192; PubMed Central PMCID: PMC2883609.

• Daniel BJ, Pandeswara S, Brumlik MJ, Liu A, Thibodeaux SR, Ludwig SM, Sun X, Curiel TJ. A simple method to detect Toxoplasma gondii-specific cytotoxic T cells in vivo. J Immunol Methods. 2010 Apr 15; 355(1-2):86-90. doi: 10.1016/j.jim.2010.01.013. Epub 2010 Feb 8. PubMed PMID: 20149795; PubMed Central PMCID: PMC2855898.